2-(naphthalen-1-yl)thiazole | 91803-21-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(naphthalen-1-yl)thiazole
• 英文别名: 2-naphthalen-1-yl-4,5-dihydro-thiazole；2-[1]naphthyl-4,5-dihydro-thiazole；2-[1]Naphthyl-4,5-dihydro-thiazol；2-(1-Naphthyl)-2-thiazolin；2-(1-Naphtyl)-2-thiazolin；2-Naphthalen-1-yl-4,5-dihydro-1,3-thiazole
• CAS: 91803-21-3
• 化学式: C₁₃H₁₁NS
• 分子量: 213.303
• InChiKey: CKQFJYOHPMTOHR-UHFFFAOYSA-N

物化性质

• 沸点：
  388.4±25.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N,N-二甲基-1-萘胺 在 bis(η3-allyl-μ-chloropalladium(II)) 、 sodium t-butanolate 、 三环己基膦 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-(naphthalen-1-yl)thiazole
  参考文献：
  名称：

  Palladium-Catalyzed C–H Arylation of (Benzo)oxazoles or (Benzo)thiazoles with Aryltrimethylammonium Triflates

  摘要：

  The C-H arylation of (benzo)oxazoles or (benzo)thiazoles with aryltrimethylammonium triflates was carried out via Pd-catalyzed C-H/C-N cleavage. Oxazoles, thiazoles, benzoxazole, and benzothiazole were arylated using activated and deactivated aryltrimethylamrnonium triflates to give 2-aryl(benzo)oxazoles or 2-aryl(benzo)thiazoles in reasonable to excellent yields.

  DOI：

  10.1021/acs.orglett.5b02458

文献信息

• Synthesis of thiazolines by the reaction of aryl ketonitriles with cysteamine<i>via</i>microwave irradiation
  作者：Sukanta Kamila、Edward R. Biehl

  DOI：10.1002/jhet.5570440220

  日期：2007.3

  Thiazolines were synthesized in a one-pot reaction in excellent yield using a newly developed methodology. Ketonitriles were directly condensed with cysteamine (2-amino-thioalcohol) via microwave irradiation at 210°C for 10 minutes under solvent free conditions and without any solid support. All the compounds were characterized by 1H nmr, 13C nmr spectroscopy and elemental analyses.

  使用一种新开发的方法，通过一锅反应以优异的产率合成了噻唑啉。在无溶剂条件下且无任何固体载体的情况下，通过在210°C微波辐射10分钟将酮腈与半胱胺（2-氨基-硫醇）直接缩合。所有化合物均通过1 H nmr，13 C nmr光谱和元素分析进行表征。
• Polymerizable copolymers for alignment layers
  申请人：Studer Peggy

  公开号：US20070179266A1

  公开（公告）日：2007-08-02

  Composition comprising at least one ethylenically unsaturated monomer to which a photochemically isomerizable or dimerizable molecule is covalently bonded, and at least one ethylenically unsaturated monomer to which a sensitizer is covalently bonded, are outstandingly suitable for producing polymeric alignment layers for liquid crystals.

  含有至少一种乙烯基不饱和单体，该单体与光化学异构化或二聚化分子共价键合，并且至少一种乙烯基不饱和单体与感光剂共价键合的组合物，非常适用于生产液晶的高分子取向层。
• Photosensitive composition
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0009223A2

  公开（公告）日：1980-04-02

  A photosensitive composition comprising a polyester composed of dicarboxylic acid units represented by the general formula (I): (in which ℓ, m, n, p and q are independently an integer of 0 or 1 but at least one of ℓ, m and n is a value of 1, X and Y are independently a hydrogen atom or X and Y are combined to form an alkylene group containing 1-4 carbon atoms) and glycol units represented by the general formula (II): (in which R represents an aklylene group containing 2-4 carbon atoms and r is an integer of 2-4) and by the general formula (III): . (in which represents a hydrogenated benzene ring, and R1 and R2 independently represent a hydrogen or an alkyl group containing 1-6 carbon atoms) as well as a photosensitive plate with a support having coated thereon a layer of this photosensitive composition.

  一种感光组合物，包含由通式(I)代表的二羧酸单元组成的聚酯： (其中 ℓ、m、n、p 和 q 独立地为 0 或 1 的整数，但 ℓ、m 和 n 中至少有一个的值为 1，X 和 Y 独立地为氢原子或 X 和 Y 组合成含 1-4 个碳原子的亚烷基）和通式（II）代表的乙二醇单元组成： (其中 R 代表含 2-4 个碳原子的亚烷基，r 为 2-4 的整数）和通式（III）代表的乙二醇单元：. (其中 R 代表氢化苯环，R1 和 R2 分别代表氢或含有 1-6 个碳原子的烷基)表示的乙二醇单元，以及具有在其上涂有一层这种感光组合物的支撑物的感光板。
• Analysis element for immunochemical measurement of trace components and for enzyme assay and methods using the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0047471A1

  公开（公告）日：1982-03-17

  In a method of assay for a trace component such as antigen, antibody or enzyme utilizing immunochemical reaction or enzyme reaction in combination with photographic detection system comprising measuring optical density of a silver image formed in proportion to the antigen, antibody or enzyme to be measured, a novel analysis sheet comprising a support having provided thereon, in succession, a water absorbing layer and a silver halide emulsion layer is employed. The analysis sheet essentially increases the amount of water absorbed so that the analysis sheet is extremely effective for improving detection sensitivity.

  在一种利用免疫化学反应或酶反应结合照相检测系统（包括测量与待测抗原、抗体或酶成比例的银图像的光密度）检测微量成分（如抗原、抗体或酶）的方法中，采用了一种新型分析片，该分析片由一个支撑物组成，支撑物上依次设有吸水层和卤化银乳剂层。该分析片从根本上增加了吸水量，因此能非常有效地提高检测灵敏度。
• Method for immunochemical measurement of trace components
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0047472A1

  公开（公告）日：1982-03-17

  In an immunochemical measurement method of an antigen or antibody which comprises competitively reacting an antigen or antibody labelled with spectral sensitizer and an antigen or antibody to be measured, bringing either the reaction product of immune reaction or the unreacted component into contact with silver halide, exposing the same to light having a wavelength which the spectral sensitizer absorbs, developing the exposed silver, and, measuring optical density of the thus formed silver image and/or colored dye, the contact with silver halide is performed in the presence of a specific hydrazine compound. Thus, detection sensitivity is markedly improved.

  在抗原或抗体的免疫化学测量方法中，包括用光谱增感剂标记的抗原或抗体与待测抗原或抗体竞争反应，使免疫反应的反应产物或未反应的成分与卤化银接触，将其暴露于光谱增感剂所吸收的波长的光下，显影所暴露的银，以及测量由此形成的银像和/或彩色染料的光密度，与卤化银的接触是在特定肼化合物存在下进行的。因此，检测灵敏度明显提高。