p-carbomethoxybenzaldehyde phenylhydrazone | 87829-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-carbomethoxybenzaldehyde phenylhydrazone
• 英文别名: 4-(phenyl-hydrazonomethyl)-benzoic acid methyl ester；(E)-methyl 4-[(2-phenylhydrazono)methyl]benzoate；methyl (E)-4-[(2-phenylhydrazono)methyl]benzoate；4-methoxycarbonylbenzaldehydehydrazone；4-(Phenylhydrazono-methyl)-benzoesaeure-methylester；Terephthalaldehydsaeuremethylester-phenylhydrazon；4-carbomethoxy-benzaldehyde phenyl-hydrazone；methyl 4-[(E)-(phenylhydrazinylidene)methyl]benzoate
• CAS: 87829-01-4
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: VYOGNCWJXUDRGP-LFIBNONCSA-N

物化性质

• 熔点：
  144-146 °C
• 沸点：
  398.8±34.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  p-carbomethoxybenzaldehyde phenylhydrazone 在 potassium carbonate 作用下， 以 乙腈 、 苯 为溶剂， 反应 5.0h， 生成 (Z)-1,4-diphenyl-2-(phenylamino)but-2-ene-1,4-dione
  参考文献：
  名称：

  Photochemical transformations of (E)-1-(2'-arylidene-1'-phenylhydrazinyl)-1,2-dibenzoylalkenes

  摘要：

  DOI：

  10.1021/jo00361a006
• 作为产物：
  描述：

  1,4-二(溴甲基)苯 在 盐酸 、 甲醇 、 lead(II) nitrate 、 水 作用下， 生成 p-carbomethoxybenzaldehyde phenylhydrazone
  参考文献：
  名称：

  Wegscheider; Suida, Monatshefte fur Chemie, 1912, vol. 33, p. 1010

  摘要：

  DOI：

文献信息

• Ion-pairing catalysis in the enantioselective addition of hydrazones to <i>N</i>-acyldihydropyrrole derivatives
  作者：Nagore Zabaleta、Uxue Uria、Efraim Reyes、Luisa Carrillo、Jose L. Vicario

  DOI：10.1039/c8cc05311a

  日期：——

  demonstrated that dihydropyrrole-based enamide derivatives can act as efficient precursors of chiral quaternary N-acyliminium salts under Brønsted acid catalysis that undergo reactions with hydrazones, the latter participating as masked nucleophilic carbonyl group equivalents. The optimized methodology provides a variety of enantiopure α-substituted proline derivatives in excellent yields, being even compatible

  我们已经证明，基于二氢吡咯烯酰胺衍生物可作为手性季的高效前体起作用Ñ下布朗斯台德酸催化的是经历与腙反应-acyliminium盐，后者参与作为掩蔽亲核羰基等价物。优化的方法以优异的产率提供了多种对映体纯的α-取代的脯氨酸衍生物，甚至与产生两个连续立体中心的二取代的β-烯酰胺相容。
• Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles
  申请人：Deng Xiaohu

  公开号：US20090093637A1

  公开（公告）日：2009-04-09

  This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.

  这项发明涉及高度取代吡唑的合成，这些化合物是药物化合物的结构成分，通过酰肼与硝基烯烃的反应实现。
• AGENT AND METHOD FOR MODIFYING THE 5' CAP OF RNA
  申请人：UNIVERSITÄT HAMBURG

  公开号：US20160032257A1

  公开（公告）日：2016-02-04

  An agent and method for modifying the 5′ cap of RNA, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synthases 2 from Giardia lamblia (GlaTGS2), the enzymatic activity of which is changed such that as compared to wild type enzymes the former can use AdoMet analogues better as cofactors.

  一种修改RNA 5'端帽的代理和方法，例如用于分离和分析。根据发明的一个方面，提供了改良的酶，即来自贾第虫（Giardia lamblia）的改良三甲基鸟苷合成酶2（GlaTGS2），其酶活性发生了变化，与野生型酶相比，前者可以更好地使用AdoMet类似物作为辅因子。
• Milcent, Rene; Barbier, Geo; Capelle, Sylvie, Journal of Heterocyclic Chemistry, 1994, vol. 31, # 2, p. 319 - 324
  作者：Milcent, Rene、Barbier, Geo、Capelle, Sylvie、Catteau, Jean-Pierre

  DOI：——

  日期：——
• Organocatalytic asymmetric hydroarylation of o-hydroxyl styrenes via remote activation of phenylhydrazones
  作者：Wei Dai、Han Lu、Xiao-Li Jiang、Ting-Ting Gao、Feng Shi

  DOI：10.1016/j.tetasy.2014.12.009

  日期：2015.2

  The first catalytic asymmetric styrene hydroarylation reaction has been established via the enantioselective Friedel-Crafts alkylations of phenylhydrazones with o-hydroxyl styrenes under the catalysis of a chiral phosphoric acid as an organocatalyst, leading to the construction of a chiral 1,1-diarylethane scaffold with high enantioselectivity (up to 89% ee). The investigation on the activation mode suggested that the two reactants, o-hydroxyl styrenes and phenylhydrazones, were simultaneously activated by the catalyst via multiple hydrogen-bonds. The remote activation of the hydrazone functionality by a dual hydrogen-bonding interaction with the catalyst contributed greatly to the hydroarylation reaction of the o-hydroxyl styrenes. (C) 2014 Elsevier Ltd. All rights reserved.