1-(2,4-Bis-trifluoromethyl-phenyl)-4-bromomethyl-1H-pyridin-2-one | 1186485-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,4-Bis-trifluoromethyl-phenyl)-4-bromomethyl-1H-pyridin-2-one
• 英文别名: 1-[2,4-bis(trifluoromethyl)phenyl]-4-(bromomethyl)pyridin-2-one
• CAS: 1186485-24-4
• 化学式: C₁₄H₈BrF₆NO
• 分子量: 400.118
• InChiKey: OUSWBKJNPQBLRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 、 1-(2,4-Bis-trifluoromethyl-phenyl)-4-bromomethyl-1H-pyridin-2-one 生成 1-(2,4-Bis-trifluoromethyl-phenyl)-4-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-1H-pyridin-2-one
  参考文献：
  名称：

  ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

  摘要：

  本发明涉及公式（I）的化合物和组合物，其药学上可接受的盐和溶剂化物，以及其制备和用于治疗由Flaviviridae病毒家族中的病毒至少部分介导的病毒感染的用途。

  公开号：

  US20090226398A1

文献信息

• Polymer bound donor-acceptor-donor compounds and their use in a 3-dimensional optical memory
  申请人：Alpert Ortal

  公开号：US20050254319A1

  公开（公告）日：2005-11-17

  The present invention is directed to a 3-dimensional optical memory comprising as an active medium a compound capable of interconverting from one isomeric form to another by interaction of light. Said compound is bound to a polymer for achieving a uniform memory unit.

  本发明涉及一种三维光学存储器，其作为活性介质的化合物能够通过光相互转换为另一异构形式。该化合物与聚合物结合以实现统一的存储单元。
• POLYMER BOUND DONOR-ACCEPTOR-DONOR COMPOUNDS AND THEIR USE IN A 3-DIMENSIONAL OPTICAL MEMORY
  申请人：Mempile Inc.

  公开号：EP1490330A2

  公开（公告）日：2004-12-29
• [EN] POLYMER BOUND DONOR-ACCEPTOR-DONOR COMPOUNDS AND THEIR USE IN A 3-DIMENSIONAL OPTICAL MEMORY<br/>[FR] COMPOSES DONATEUR-ACCEPTEUR-DONATEUR LIES A UN POLYMERE ET LEUR UTILISATION DANS UNE MEMOIRE OPTIQUE TRIDIMENSIONNELLE
  申请人：MEMPILE INC

  公开号：WO2003070689A2

  公开（公告）日：2003-08-28

  The present invention is directed to a 3-dimensional optical memory comprising as an active medium a compound capable of interconverting from one isomeric form to another by interaction of light. Said compound is bound to a polymer for achieving a uniform memory unit.
• [EN] NEW DONOR-ACCEPTOR-DONOR-ACCEPTOR COMPOUNDS FOR NON-LINEAR APPLICATIONS<br/>[FR] NOUVEAUX COMPOSÉS DONNEUR-ACCEPTEUR-DONNEUR-ACCEPTEUR POUR DES APPLICATIONS NON-LINÉAIRES
  申请人：MEMPILE INC

  公开号：WO2009010947A1

  公开（公告）日：2009-01-22

  The present invention is directed to compounds having strong 2-photon absorbance for the manufacture of polymers suitable for various electro-optic applications.
• [EN] DERIVATIVES OF IMIDAZO [4, 5-D] PYRIDAZINE AND THEIR USE AS ANTI-VIRAL COMPOUNDS<br/>[FR] DÉRIVÉS D'IMIDAZO[4,5-D]PYRIDAZINE ET LEUR UTILISATION EN TANT QUE COMPOSÉS ANTIVIRAUX
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2009111501A1

  公开（公告）日：2009-09-11

  Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.