1-[Bis-(2-hydroxy-ethyl)-amino]-octan-2-ol | 13197-77-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[Bis-(2-hydroxy-ethyl)-amino]-octan-2-ol
• 英文别名: 1-[Bis(2-hydroxyethyl)amino]octan-2-ol
• CAS: 13197-77-8
• 化学式: C₁₂H₂₇NO₃
• 分子量: 233.351
• InChiKey: ZIRDTXUGLCYRNS-UHFFFAOYSA-N

物化性质

• 沸点：
  388.1±22.0 °C(Predicted)
• 密度：
  1.029±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二乙醇胺 、 1,2-环氧辛烷 以 neat (no solvent) 为溶剂， 反应 66.0h， 以99%的产率得到1-[Bis-(2-hydroxy-ethyl)-amino]-octan-2-ol
  参考文献：
  名称：

  Organic Synthesis “on Water” vs “on Liquids”: A Comparative Analysis

  摘要：

  Several organic reactions that are accelerated under the "on water" conditions proceed equally well or better on other "nonsolvents" or in neat conditions. Alternatively, only 1 equiv of water was necessary to obtain the same acceleration effect testifying to the fact that the water-organic compounds boundary might be unnecessary to achieve the "on water"-like reactivity.

  DOI：

  10.1021/ol500518n

文献信息

• US4549885A
  申请人：——

  公开号：US4549885A

  公开（公告）日：1985-10-29
• US4549882A
  申请人：——

  公开号：US4549882A

  公开（公告）日：1985-10-29
• Organic Synthesis “on Water” vs “on Liquids”: A Comparative Analysis
  作者：Tal Sela、Arkadi Vigalok

  DOI：10.1021/ol500518n

  日期：2014.4.4

  Several organic reactions that are accelerated under the "on water" conditions proceed equally well or better on other "nonsolvents" or in neat conditions. Alternatively, only 1 equiv of water was necessary to obtain the same acceleration effect testifying to the fact that the water-organic compounds boundary might be unnecessary to achieve the "on water"-like reactivity.