NK-130119 | 132707-68-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: NK-130119
• 英文别名: 44-HomooIigomycin A；(1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14S,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22,28-diethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,29-octamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,9,13-trione
• CAS: 132707-68-7
• 化学式: C₄₆H₇₆O₁₁
• 分子量: 805.103
• InChiKey: APJPYXAUMOLFTM-XJCHUAJNSA-N

物化性质

• 沸点：
  893.6±65.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  57
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  180
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
  申请人：DeFrees Shawn

  公开号：US20080050772A1

  公开（公告）日：2008-02-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Glycoconjugation methods and proteins/peptides produced by the methods
  申请人：DeFrees Shawn

  公开号：US20080146494A1

  公开（公告）日：2008-06-19

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Erythropoietin: remodeling and glycoconjugation of erythropoietin
  申请人：DeFrees Shawn

  公开号：US20080187955A1

  公开（公告）日：2008-08-07

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• GALACTOSYL NUCLEOTIDE SUGAR
  申请人：DeFrees Shawn

  公开号：US20080206808A1

  公开（公告）日：2008-08-28

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
• Factor IX: remodeling and glycoconjugation of factor IX
  申请人：DeFrees Shawn

  公开号：US20080305991A1

  公开（公告）日：2008-12-11

  The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.