6,7-dimethoxy-1-phenyl-3,4-dihydronaphthalene-2-carbaldehyde | 883221-05-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6,7-dimethoxy-1-phenyl-3,4-dihydronaphthalene-2-carbaldehyde
• 英文别名: 6,7-Dimethoxy-1-phenyl-3,4-dihydronaphthalene-2-carbaldehyde
• CAS: 883221-05-4
• 化学式: C₁₉H₁₈O₃
• 分子量: 294.35
• InChiKey: JJOKWVJNYUSIOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-1-phenyl-3,4-dihydronaphthalene-2-carbaldehyde 在 吡啶 、 sodium tetrahydroborate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (6,7-dimethoxy-1-phenylnaphthalen-2-yl)methyl acetate
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013
• 作为产物：
  描述：

  6,7-二甲氧基-3,4-二氢-2H-1-萘酮 在 四(三苯基膦)钯 三溴化磷 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 14.0h， 生成 6,7-dimethoxy-1-phenyl-3,4-dihydronaphthalene-2-carbaldehyde
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013

文献信息

• Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones
  作者：Simon S. Moleele、Joseph P. Michael、Charles B. de Koning

  DOI：10.1016/j.tet.2006.01.013

  日期：2006.3

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.