1-(5-bromopentyloxy)naphthalene | 93372-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(5-bromopentyloxy)naphthalene
• 英文别名: 1-(5-Bromopentoxy)naphthalene
• CAS: 93372-51-1
• 化学式: C₁₅H₁₇BrO
• 分子量: 293.203
• InChiKey: OMUZFQCMWADMPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(5-bromopentyloxy)naphthalene 在 三氟化硼乙醚 、 potassium carbonate 作用下， 以 氯仿 、 丙酮 为溶剂， 反应 102.0h， 生成 5,10,15-triphenyl-20-[4-(5-naphthoxy)pentyloxy]phenyl porphyrin
  参考文献：
  名称：

  新型取代卟啉：TiO2 基复合材料的合成、表征和光催化活性

  摘要：

  合成了四种新型卟啉及其相应的锌配合物，并对其进行了光谱表征。通过在可见光下光降解水溶液中的甲基橙，研究了 TiO2-卟啉杂化体系中卟啉外围取代基的间隔长度的影响。通过扫描X射线衍射、UV-Vis光谱、X射线光电子能谱和FT-IR光谱对光催化剂进行了表征。结果表明，锌卟啉成功负载并与TiO2微球表面相互作用，这对于提高催化复合材料在可见光下的活性至关重要。所有新的光催化剂都表现出比裸 TiO2 大大增强的光活性。尤其是5,10的光催化活性，

  DOI：

  10.1007/s10847-017-0724-6
• 作为产物：
  描述：

  萘酚 生成 1-(5-bromopentyloxy)naphthalene
  参考文献：
  名称：

  STOKBROEKX, RAYMOND A.;LUYCKX, MARCEL G. M.;JANSSENS, FRANS E.

  摘要：

  DOI：

文献信息

• Novel naphthyloxy derivatives – Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation
  作者：Dorota Łażewska、Maria Kaleta、Stefanie Hagenow、Szczepan Mogilski、Gniewomir Latacz、Tadeusz Karcz、Annamaria Lubelska、Ewelina Honkisz、Jadwiga Handzlik、David Reiner、Grzegorz Satała、Barbara Filipek、Holger Stark、Katarzyna Kieć-Kononowicz

  DOI：10.1016/j.bmc.2018.04.023

  日期：2018.5

  A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H3 receptor affinity. Most compounds showed high affinities with Ki values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy)pentyl)azepane (11) displayed high affinity for the histamine H3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP

  合成了一系列的1-和2-萘氧基衍生物，并评估了组胺H3受体的亲和力。大多数化合物显示出高亲和力，Ki值低于100 nM。最有效的配体1-（5-（萘-1-基氧基）戊基）ep庚烷（11）对组胺H3受体表现出高亲和力，Ki值为21.9 nM。在体外cAMP分析中（IC50 = 312 nM）和在大鼠成药模型中体内（ED50 = 3.68 nM）都证实了11的拮抗剂行为。此外，化合物11对东碱引起的小鼠记忆力减退（剂量为10和15 mg / kg）具有积极作用，在福尔马林试验中对ED50 = 30.6 mg / kg（早期）和ED50 =的小鼠具有镇痛作用。 20.8 mg / kg（晚期）。另一种有趣的化合物是1-（5-（萘-1-基氧基）戊基）哌啶（13; H3R Ki = 53.9 nM），被美国国家神经系统疾病和中风研究所/美国国立卫生研究院接受抗惊厥筛查计划。筛选是在最大电击癫痫发作（ME
• Antinociceptive effects of novel histamine H ₃ and H ₄ receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse
  作者：Katarzyna Popiolek‐Barczyk、Dorota Łażewska、Gniewomir Latacz、Agnieszka Olejarz、Wioletta Makuch、Holger Stark、Katarzyna Kieć‐Kononowicz、Joanna Mika

  DOI：10.1111/bph.14185

  日期：2018.7

  development of new analgesics, as histamine H3 and H4 receptors are expressed in regions concerned with nociceptive transmission. Here we have determined the analgesic effects of new H3 and H4 receptor antagonists in naive and neuropathic mice. EXPERIMENTAL APPROACH We used chronic constriction injury (CCI) to the sciatic nerve in mice to model neuropathy. Effects of a new H3 receptor antagonist, E-162(1-(

  背景和目的组胺能系统是开发新型镇痛药的一个有希望的目标，因为组胺H3和H4受体在与伤害性传播有关的区域表达。在这里，我们确定了新的 H3 和 H4 受体拮抗剂对幼鼠和神经病小鼠的镇痛作用。实验方法我们使用小鼠坐骨神经的慢性压迫性损伤（CCI）来模拟神经病变。新型 H3 受体拮抗剂 E-162(1-(5-(萘-1-基氧基)戊基)哌啶) 和 H4 受体拮抗剂 TR-7(4-(4-氯苯基)-6-(4-) 的作用甲基哌嗪-1-基）-1,3,5-三嗪-2-胺）在有和没有CCI（损伤后7天）的小鼠中评估机械（von Frey）和热（冷板、甩尾）刺激。还评估了这些拮抗剂对吗啡镇痛的作用，以及 H1 受体可能参与其作用。我们在 H3 和 H4 受体的结合和功能性 cAMP 测定中分析了化合物，并确定了代谢稳定性。主要结果 E-162 和 TR-7 减弱了 CCI 男性的伤害性反应和深度吗啡镇痛作用。这些拮
• Design, synthesis, and anti-HCV activity of thiourea compounds
  作者：Iou-Jiun Kang、Li-Wen Wang、Chung-Chi Lee、Yen-Chun Lee、Yu-Sheng Chao、Tsu-An Hsu、Jyh-Haur Chern

  DOI：10.1016/j.bmcl.2009.02.048

  日期：2009.4

  A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC50 = 0.047 mu M) with a selectivity index of 596. (C) 2009 Elsevier Ltd. All rights reserved.
• Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors
  作者：Iou-Jiun Kang、Li-Wen Wang、Sheng-Ju Hsu、Chung-Chi Lee、Yen-Chun Lee、Yen-Shian Wu、Tsu-An Hsu、Andrew Yueh、Yu-Sheng Chao、Jyh-Haur Chern

  DOI：10.1016/j.bmcl.2009.06.009

  日期：2009.8

  An efficient synthetic methodology to provide indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives is described. These conformationally restricted heterobicyclic scaffolds were evaluated as a novel class of HCV inhibitors. Introduction of an acyl group at the NH2 of the thiourea moiety has been found to enhance inhibitory activity. The chain length and the position of the alkyl group on the indoline aromatic ring markedly influenced anti-HCV activity. The indoline scaffold was more potent than the corresponding indole and tetrahydroquinoline scaffolds and analogue 31 displayed excellent activity (EC50 = 510 nM) against HCV without significant cytotoxicity (CC50 > 50 mu M). (C) 2009 Elsevier Ltd. All rights reserved.
• Alfer'ev, I. S.; Vainer, L. M.; Krainev, A. G., Doklady Chemistry, 1984, vol. 277, p. 233 - 236
  作者：Alfer'ev, I. S.、Vainer, L. M.、Krainev, A. G.、Slyn'ko, N. M.

  DOI：——

  日期：——