1-Thiophen-2-yl-ethanethione | 97564-65-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 1-Thiophen-2-yl-ethanethione
• 英文别名: 1-Thiophen-2-ylethanethione；1-thiophen-2-ylethanethione
• CAS: 97564-65-3
• 化学式: C₆H₆S₂
• 分子量: 142.246
• InChiKey: PELPZJHHJQCQRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯乙酮 、 1-Thiophen-2-yl-ethanethione 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 为溶剂， 以75 %的产率得到2-(2-thienyl)-4-phenylthiazole
  参考文献：
  名称：

  Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach

  摘要：

  A novel approach for the synthesis of 2,4-disubstituted thiazoles from methyl aryl ketones, N-bromo-succinimide (NBS), and thioamide in water as a green reaction medium through visible-light irradiation is reported.

  DOI：

  10.1039/d4ob00096j

文献信息

• Mayer, R.; Hartenhauer, H.; Gruner, M., Journal fur praktische Chemie (Leipzig 1954), 1991, vol. 333, # 1, p. 35 - 40
  作者：Mayer, R.、Hartenhauer, H.、Gruner, M.

  DOI：——

  日期：——
• A METHOD FOR PREPARING OPTICALLY ACTIVE CARBONYL COMPOUND
  申请人：ZHEJIANG NHU COMPANY LTD.

  公开号：US20180105477A1

  公开（公告）日：2018-04-19

  The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.
• Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach
  作者：Khushbu Rajput、Vishal Singh、Priya Mahaur、Sundaram Singh、Vandana Srivastava

  DOI：10.1039/d4ob00096j

  日期：2024.4.3

  A novel approach for the synthesis of 2,4-disubstituted thiazoles from methyl aryl ketones, N-bromo-succinimide (NBS), and thioamide in water as a green reaction medium through visible-light irradiation is reported.