7-(4-methoxyphenyl)-6H,7H-naphtho[1,2:5,6]pyrano[3,2-c]chromen-6-one | 1346003-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 7-(4-methoxyphenyl)-6H,7H-naphtho[1,2:5,6]pyrano[3,2-c]chromen-6-one
• 英文别名: 12-(4-methoxyphenyl)dibenzo[i,b]pyrano[4,3-b]chromen-11(12H)-one；7-(4-Methoxyphenyl)-6h,7h-benzo[f]chromeno[4,3-b]chromen-6-one；13-(4-methoxyphenyl)-2,10-dioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-1(14),3(12),4,6,8,15,17,19,21-nonaen-11-one
• CAS: 1346003-62-0
• 化学式: C₂₇H₁₈O₄
• 分子量: 406.438
• InChiKey: YGJFHXVBYHNKJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 4-甲氧基苯甲醛 、 2-萘酚 在 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride 作用下， 反应 2.0h， 以90%的产率得到7-(4-methoxyphenyl)-6H,7H-naphtho[1,2:5,6]pyrano[3,2-c]chromen-6-one
  参考文献：
  名称：

  1-甲基-3-（2-（磺氧基） ）乙基）-1H-咪唑-3-氯化铵

  摘要：

  β-萘酚与芳烃的三组分缩合反应可有效合成7-烷基-6 H，7 H萘[10,20：5,6]吡喃并[3,2 - c ]铬-6-酮据报道，1-甲基-3-（2-（磺氧基）乙基）-1 H-咪唑-3-氯化铵催化的乙醛和4-羟基香豆素的收率好至极好，反应时间短。

  DOI：

  10.1002/jhet.1658

文献信息

• 3,3-(Butane-1,4-diyl)bis(1,2-dimethyl-1H-imidazole-3-ium)bromide–cerium(IV) ammonium nitrate: A novel reagent for mild synthesis of 12-aryldibenzo[i,b]pyrano[4,3-b]chromenone of benzyl alcohols
  作者：Z. Gharib、M. Nikpassand

  DOI：10.1134/s1070363216120379

  日期：2016.12

  A novel and efficient procedure for the synthesis of pyrano[4,3-b]chromene derivatives via three-component condensation reaction of benzyl alcohol, β-naphthol, and 4-hydroxycoumarin using a catalytical amount of cerium(IV) ammonium nitrate (CAN) and a reusable ionic liquid as a catalyst at room temperature is presented. The method provides several advantages such as simple work-up, environmental friendliness

  通过催化量的硝酸铈（IV）铵（苄基乙醇），β-萘酚和4-羟基香豆素的三组分缩合反应合成吡喃并[4,3- b ]苯二甲基衍生物的新方法），并提出了一种在室温下可重复使用的离子液体作为催化剂。该方法具有一些优点，例如后处理简单，环境友好，反应时间短以及产率高。通过与真实样品进行比较，IR，1 H和13 C NMR光谱以及元素分析，阐明了所有合成的化合物。
• Synthesis and evaluation of antimicrobial and antioxidant activity of novel 7‐Aryl‐6H,7H‐ benzo[f]chromeno[4,3‐b]chromen‐6‐one by MgO nanoparticle as green catalyst
  作者：Sara Hosseinzadegan、Nourallah Hazeri、Malek T. Maghsoodlou

  DOI：10.1002/jhet.3796

  日期：2020.2

  a recyclable and efficient catalyst, multicomponent reaction of 2‐Naphthol, aldehyde derivatives, 4‐hydroxycoumarin has led to the synthesis of novel 7‐Aryl‐6H,7H‐ benzo[f]chromeno[4,3‐b]chromen‐6‐one derivatives. This study aimed to examine the antimicrobial and antioxidant effects of the synthetic compound in order to reach some benefits, including the synthesis of new derivatives with biological

  使用的MgO粒子作为可回收的和高效的催化剂，的多组分反应2-萘酚，醛衍生物，4 -羟基香豆素已导致新的7-芳基- 6H的合成，7H-苯并[f]色烯并[4,3-B] chromen-6-one衍生物。这项研究旨在检查合成化合物的抗微生物和抗氧化作用，以期获得一些好处，包括合成具有生物学特性，较短时间，高收率并符合绿色化学要求的新衍生物。
• POTASSIUM 2-OXOIMIDAZOLIDINE-1,3-DIIDE AS A NOVEL CATALYST FOR GRIND SYNTHESIS OF PYRANO[4,3- b ]CHROMENONE
  作者：Mohammad Nikpassand、Leila Zare Fekri、Zahra Gharib、Zeinab Jafariana

  DOI：10.4067/s0717-97072018000404195

  日期：——

  A novel, clean, mild and eco-friendly benign route to pyrano[4,3-b]chromenes through cyclocondensation reaction of beta-naphthol, aldehydes and 4-hydroxycoumarin, using POImD as a novel and reusable organometallic catalyst. is described. The present methodology offers several advantages such as simple work-up procedure. short reaction time, high yields of product with better purity and green aspect by avoiding toxic catalyst and hazardous solvent. All of synthesized compounds were characterized by IR, NMR and elemental analyses.
• Xie, Youhai; Wang, Yingling; Wu, Liqiang, Asian Journal of Chemistry, 2011, vol. 23, # 12, p. 5377 - 5380
  作者：Xie, Youhai、Wang, Yingling、Wu, Liqiang

  DOI：——

  日期：——
• Efficient One-Pot Syntheses of 7-Alkyl-6<i>H</i>,7<i>H</i>-naphtho[1,2:5,6]pyrano-[3,2-<i>c</i>]chromen-6-ones by 1-Methyl-3-(2-(sulfooxy)ethyl)-1<i>H</i>-imidazol-3-ium Chloride
  作者：Yu Wan、Chao Wang、Hai-ying Wang、Ling-ling Zhao、Xiao-xiao Zhang、Jing-jing Shi、Shu-ying Huang、Gui-Xiang Liu、Hui Wu

  DOI：10.1002/jhet.1658

  日期：2014.9

  An efficient synthesis of 7‐alkyl‐6H,7H‐naphtho‐[10,20:5,6]pyrano[3,2‐c]chromen‐6‐ones by three‐component condensation reaction of β‐naphthol, aromatic aldehydes, and 4‐hydroxycoumarin catalyzed by 1‐methyl‐3‐(2‐(sulfooxy)ethyl)‐1H‐imidazol‐3‐ium chloride is reported in good to excellent yields and short reaction times.

  β-萘酚与芳烃的三组分缩合反应可有效合成7-烷基-6 H，7 H萘[10,20：5,6]吡喃并[3,2 - c ]铬-6-酮据报道，1-甲基-3-（2-（磺氧基）乙基）-1 H-咪唑-3-氯化铵催化的乙醛和4-羟基香豆素的收率好至极好，反应时间短。