1-[(3,4-Dimethoxyphenyl)-pyrrolidin-1-ylmethyl]naphthalen-2-ol | 1334232-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[(3,4-Dimethoxyphenyl)-pyrrolidin-1-ylmethyl]naphthalen-2-ol
• 英文别名: 1-[(3,4-dimethoxyphenyl)-pyrrolidin-1-ylmethyl]naphthalen-2-ol
• CAS: 1334232-94-8
• 化学式: C₂₃H₂₅NO₃
• 分子量: 363.456
• InChiKey: AVLSCOLZRSPMHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 3,4-二甲氧基苯甲醛 、 2-萘酚 在 magnesium oxide 作用下， 以 水 为溶剂， 反应 3.5h， 以82%的产率得到1-[(3,4-Dimethoxyphenyl)-pyrrolidin-1-ylmethyl]naphthalen-2-ol
  参考文献：
  名称：

  A competent pot and atom-efficient synthesis of Betti bases over nanocrystalline MgO involving a modified Mannich type reaction

  摘要：

  A simple, efficient, and eco-friendly method for the synthesis of 1-(alpha-aminoalkyl) naphthols, the Betti bases, has been carried out over a basic nanocrystalline MgO catalyst in aqueous condition. The method has been applied for the synthesis of a range of compounds with variable functionalities in excellent yield and selectivity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.075

文献信息

• Gold nanoparticles deposited on MnO2 nanorods modified graphene oxide composite: A potential ternary nanocatalyst for efficient synthesis of betti bases and bisamides
  作者：Pratap S. Nayak、Bapun Barik、L. Satish K. Achary、Aniket Kumar、Priyabrat Dash

  DOI：10.1016/j.mcat.2019.110415

  日期：2019.9

  The decoration of novel nanostructures such as nano particle and nanorod on the surface of graphene oxide (GO) generate potential heterogeneous nanocatalyst. Highlighting this, in the present work, we have designed a ternary GO-MnO2-Au nanocomposite by decorating MnO(2)nanorods on the surface of graphene oxide via hydrothermal method, followed by deposition of Au nanoparticles on GO-MnO2 surface. The prepared nanocomposite was thoroughly characterised by different instrumental techniques such as X-Ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR),Raman spectroscopy, Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), High resolution Transmission electron microscopy (HRTEM), X-Ray photo electron spectroscopy (XPS), N-2 adsorption desorption Brunauer-Emmett-Teller (BET) isotherm and Inductively coupled plasma - optical emission spectrometry (ICP-OES). FESEM and TEM images demonstrated that the MnO2 forms rod like structure having diameter of 60-100 nm and are uniformly distributed over the GO surface. HRTEM image clearly signifies gold (Au) nano particles having diameter of 7 +/- 1.9 nm homogeneously distributed throughout the GO-MnO2 surface. Elementary state of Au and tetravalent nature of Mn as well as reduction of functional group after the decoration was confirmed from XPS studies. The catalyst GO-MnO2-Au was found to be the superior catalyst for synthesis of biologically active molecules such as Beni bases and Bisamides. The high catalytic activity of the materials can be attributed to the small and homogeneous distribution of gold nanoparticles, high redox potential of rod shaped MnO2 and the synergistic effect between GO, MnO2 and Au. All the reaction conditions were optimised by varying catalyst dosage, effect of solvent and temperature, The GO-MnO2-Au was easily recycled with minimal leaching and the product yield was found to be 85-90% after 4th cycle demonstrating the stability and durability of our nanocomposite.
• A competent pot and atom-efficient synthesis of Betti bases over nanocrystalline MgO involving a modified Mannich type reaction
  作者：Bikash Karmakar、Julie Banerji

  DOI：10.1016/j.tetlet.2011.07.075

  日期：2011.9

  A simple, efficient, and eco-friendly method for the synthesis of 1-(alpha-aminoalkyl) naphthols, the Betti bases, has been carried out over a basic nanocrystalline MgO catalyst in aqueous condition. The method has been applied for the synthesis of a range of compounds with variable functionalities in excellent yield and selectivity. (C) 2011 Elsevier Ltd. All rights reserved.