di-n-butylphosphinothioyl bromide | 55656-88-7

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机硫代磷化合物
• 英文名称: di-n-butylphosphinothioyl bromide
• 英文别名: bromo-dibutyl-sulfanylidene-λ5-phosphane
• CAS: 55656-88-7
• 化学式: C₈H₁₈BrPS
• 分子量: 257.175
• InChiKey: ORWNUZMZIHRSRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  di-n-butylphosphinothioyl bromide 在 4-二甲氨基吡啶 、 叔丁胺 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 0.25h， 生成 Dibutyl-phosphinothioic acid O-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(trityl-amino)-9H-purin-6-yl] ester
  参考文献：
  名称：

  Daskalov, Hristo Petrov; Sekine, Mitsuo; Hata, Tsujiaki, Bulletin of the Chemical Society of Japan, 1981, vol. 54, # l0, p. 3076 - 3083

  摘要：

  DOI：
• 作为产物：
  描述：

  三氯硫磷 在 溴 作用下， 以 四氯化碳 为溶剂， 生成 di-n-butylphosphinothioyl bromide
  参考文献：
  名称：

  Synthesis of cytidine diphosphate-d-quinovose

  摘要：

  DOI：

  10.1016/s0040-4039(01)80315-4

文献信息

• Synthesis of a novel acceptor substrate for a mannosyl transferase
  作者：Sabine L. Flitsch、James P. Taylor、Nicholas J. Turner

  DOI：10.1039/c39910000380

  日期：——

  Two novel analogues of the mannosyl transferase acceptor substrate (GlcNAc)2-pyrophosphate-dolichyl 2 have been prepared in which dolichyl is replaced by phytanyl 4 and lauryl 5; both 4 and 5 were synthesised using readily available chitin as the disaccharide precursor.

  两种新型甘露糖基转移酶受体底物（N-乙酰葡糖胺）2-焦磷酸-dolichyl 2的类似物已被制备，其中dolichyl被phytanyl 4和lauryl 5取代；两者均使用易于获得的甲壳素作为二糖前体合成。
• New guanosine derivatives: facile O6-phosphorylation, thiophosphinylation sulfonylation and silylation of guanosine derivatives by 4-dimethylaminopyridine catalized reaction
  作者：Hristo Petrov Daskalov、Mitsuo Sekine、Tsujiaki Hata

  DOI：10.1016/0040-4039(80)80211-5

  日期：1980.1

  Appropriately protected guanosine derivatives were successfully converted to the corresponding O6-substituted guanosine derivatives by treatment with dialkyl- or diaryl-phosphoryl halides, dialkyl- or diaryl-phosphinothioyl halides, arenesulfonyl chlorides, and trialkylsilyl chlorides.

  通过用二烷基或二芳基-磷酰卤，二烷基或二芳基-膦硫酰卤，芳烃磺酰氯和三烷基甲硅烷基氯处理，将适当保护的鸟苷衍生物成功转化为相应的O 6取代的鸟苷衍生物。
• Stereocontrolled synthesis of nucleoside-methylphosphonate-methyl ester diastereomers from mixed anhydride
  作者：Morteza M. Vaghefi、Kelly A. Langley

  DOI：10.1016/0040-4039(96)00974-4

  日期：1996.7

  Nucleoside-3′-methylphosphonate was converted to a diastereomeic mixture of di-n-butylphosphiothioic anhydride and the stereoisomers were separated. Activation of each isomer with silver nitrate and coupling with methanol resulted in the formation of a methyl ester with inversion of configuration.

  将核苷3'-甲基膦酸酯转化为二正丁基硫代磷酸二酐的非对映异构混合物，并分离出立体异构体。每种异构体被硝酸银活化并与甲醇偶合导致形成甲基，其构型反转。
• Synthesis and Characterization of the (5? ? 5?)-Ester of Adenosine 5?-diphosphate with ?-D-ribofuranose cyclic 1?,2?-phosphate: A NAD derivative produced during tRNA splicing
  作者：Jonathan Hall、Pascal Genschik、Witold Filipowicz

  DOI：10.1002/hlca.19960790409

  日期：1996.6.26

  The synthesis and spectroscopic properties of the (5′ 5″)-ester of adenosine 5′-diphosphate with ribofuranose cyclic 1″, 2″-phosphate 3, a recently discovered metabolite produced during tRNA splicing, are reported.

  报道了腺苷5'-二磷酸（5'5''）-酯与呋喃核糖环1''，2''-磷酸3（一种最近发现的在tRNA剪接过程中产生的代谢物）的合成和光谱性质。
• COMPOUNDS, METHODS, COMPLEXES, APPARATUSES AND USES RELATING TO STABILE FORMS OF NAD/NADH
  申请人：Heindl Dieter

  公开号：US20090246818A1

  公开（公告）日：2009-10-01

  The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their use in biochemical detection methods and reagent matrices.

  这项发明涉及稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物以及它们在生化检测方法和试剂基质中的应用。