(S)-1-(phenyltellanyl)-propan-2-ol | 915040-54-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-(phenyltellanyl)-propan-2-ol
• 英文别名: (2S)-1-phenyltellanylpropan-2-ol
• CAS: 915040-54-9
• 化学式: C₉H₁₂OTe
• 分子量: 263.794
• InChiKey: PHNINCMRTLIHTJ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (S)-1-(phenyltellanyl)-propan-2-ol 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以50%的产率得到(1S,2S')-1-methyl-2-(phenyltellanyl)ethyl 3',3',3'-trifluoro-2'-methoxy-2'-phenylpropionate
  参考文献：
  名称：

  Lipase-catalyzed kinetic resolution of (RS)-hydroxy tellurides

  摘要：

  The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.024
• 作为产物：
  描述：

  乙酸乙烯酯 、 1-(phenyltellanyl)propan-2-ol 在 CAL-B enzymme 作用下， 以 supercritical CO₂ 为溶剂， 37.0 ℃ 、23.17 MPa 条件下， 反应 2.72h， 以40%的产率得到(S)-1-(phenyltellanyl)-propan-2-ol
  参考文献：
  名称：

  Enzymatic kinetic resolution of organochalcogenides in supercritical CO2

  摘要：

  1-(Phenylthio)-, 1-(phenylseleno)- and 1-(phenyltelluro)-propan-2-ol were efficiently resolved by CAL-B in sc-CO2. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.073

文献信息

• Lipase-catalyzed kinetic resolution of (RS)-hydroxy tellurides
  作者：Alcindo A. Dos Santos、Carlos E. Da Costa、Jefferson L. Princival、João V. Comasseto

  DOI：10.1016/j.tetasy.2006.07.024

  日期：2006.9

  The enzymatic resolution of racemic mixtures of hydroxy tellurides with a range of lipases has been investigated. Lipase-B from Candida antarctica (CALB) gave the best conversions, providing both enantiomers with high enantiomeric purity. A comparative study of the effect of solvent and substrate on the enzymatic kinetic resolution was performed. (c) 2006 Elsevier Ltd. All rights reserved.
• Enzymatic kinetic resolution of organochalcogenides in supercritical CO2
  作者：Rogério A. Gariani、Fernando A.G. Luengo、Luiz A.S. Vale、Reinaldo C. Bazito、João V. Comasseto

  DOI：10.1016/j.tetlet.2011.04.073

  日期：2011.6

  1-(Phenylthio)-, 1-(phenylseleno)- and 1-(phenyltelluro)-propan-2-ol were efficiently resolved by CAL-B in sc-CO2. (C) 2011 Elsevier Ltd. All rights reserved.