2-(9-oxo-9H-fluoren-2-yl)acetic acid | 53076-71-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(9-oxo-9H-fluoren-2-yl)acetic acid
• 英文别名: 9-Ketofluoren-2-essigsaeure；2-(9-Oxo-9H-fluoren-2-yl)acetic acid；2-(9-oxofluoren-2-yl)acetic acid
• CAS: 53076-71-4
• 化学式: C₁₅H₁₀O₃
• 分子量: 238.243
• InChiKey: IGTMULJZPOLSGC-UHFFFAOYSA-N

物化性质

• 沸点：
  481.0±24.0 °C(Predicted)
• 密度：
  1.382±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-吡嗪-2-基吡啶-2-胺 、 2-(9-oxo-9H-fluoren-2-yl)acetic acid 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以31%的产率得到2-(9-oxo-9H-fluoren-2-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
  参考文献：
  名称：

  Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

  摘要：

  The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane -bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.11.026
• 作为产物：
  描述：

  tert-butyl 2-(9-oxo-9H-fluoren-2-yl)acetate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以84%的产率得到2-(9-oxo-9H-fluoren-2-yl)acetic acid
  参考文献：
  名称：

  Photochromism of dihydroindolizines. Part XVIII: palladium-catalyzed Negishi coupling for the synthesis of photochromic dihydro 5-azaindolizine-linker-conjugates with a terminal ethylene anchoring group

  摘要：

  Eight new photochromic dihydro 5-azaindolizine-linker-conjugates with a terminal ethylene anchoring group have been synthesized via palladium-catalyzed Negishi coupling. Polychromatic light irradiation of the photochromic dihydro 5-azaindolizines (DHAIs) led to ring-opened colored betaines which underwent reversible thermal 1,5-electrocyclization into their corresponding DHAIs in the second domain. The noteworthy multiaddressable photochromic properties are useful for a plethora of new applications for these materials such as anchoring the ethylene group to metal-oxide nanoparticles. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.039

文献信息

• THERMALLY DECOMPOSABLE POLYMER COMPOSITIONS INCORPORATING THERMALLY ACTIVATED BASE GENERATORS
  申请人：Tsang W. C. Peter

  公开号：US20120318854A1

  公开（公告）日：2012-12-20

  Embodiments in accordance with the present invention provide sacrifical polymer compositions and methods for fabricating electronic devices using such sacrifical polymer compositions where such methods include (1) providing a tacky sacrifical polymer composition that holds components in a desired alignment to one another, (2) providing solder fluxing for effecting electrical coupling; and (3) thermal decomposition or depolymerization of the sacrificial polymer composition to provide essentially residue free surfaces.
• US20140275316A1
  申请人：——

  公开号：US20140275316A1

  公开（公告）日：2014-09-18
• THERMALLY DECOMPOSABLE POLYMER COMPOSITIONS FOR FORMING MICROELECTRONIC ASSEMBLIES
  申请人：PROMERUS LLC

  公开号：US20150299509A1

  公开（公告）日：2015-10-22

  Embodiments in accordance with the present invention relate generally to polymer compositions useful in the forming of microelectronic assemblies, and more specifically to such compositions that encompass a thermally decomposable polymer and that provide both tackiness and solder fluxing.
• US9115300B2
  申请人：——

  公开号：US9115300B2

  公开（公告）日：2015-08-25
• US9505948B2
  申请人：——

  公开号：US9505948B2

  公开（公告）日：2016-11-29