2-(2-methoxy-ethoxy)-tetrahydro-pyran | 4819-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-(2-methoxy-ethoxy)-tetrahydro-pyran
• 英文别名: 2-<2-Methoxy-aethoxy>-tetrahydropyran；2-(2-Methoxyethoxy)-tetrahydro-2H-pyran；2-(2-methoxyethoxy)oxane
• CAS: 4819-82-3
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: CENLRESKVLHEPM-UHFFFAOYSA-N

物化性质

• 沸点：
  215.6±30.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-methoxy-ethoxy)-tetrahydro-pyran 在 甲醇 作用下， 反应 0.5h， 以97%的产率得到乙二醇甲醚
  参考文献：
  名称：

  Synthesis of sulfonic acid functionalized carbon catalyst from glycerol pitch and its application for tetrahydropyranyl protection/deprotection of alcohols and phenols

  摘要：

  A novel carbon catalyst with -SO3H, -OH and -COOH functional groups was prepared from glycerol pitch by in situ partial carbonization and sulfonation with sulfuric acid. The activity of the catalyst was investigated through tetrahydropyranylation and dehydropyranylation of a wide variety of alcohols and phenols at room temperature by changing the solvent medium from dichloromethane to methanol. Excellent yields, short reaction times, easy and quick isolation of the products and reusability of the catalyst are the main attractions of this method. The novel carbon catalyst holds great potential in the green chemical processes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.05.025
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 乙二醇甲醚 在 sulfonic acid functionalized polycyclic aromatic carbon catalyst from glycerol pitch 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到2-(2-methoxy-ethoxy)-tetrahydro-pyran
  参考文献：
  名称：

  Synthesis of sulfonic acid functionalized carbon catalyst from glycerol pitch and its application for tetrahydropyranyl protection/deprotection of alcohols and phenols

  摘要：

  A novel carbon catalyst with -SO3H, -OH and -COOH functional groups was prepared from glycerol pitch by in situ partial carbonization and sulfonation with sulfuric acid. The activity of the catalyst was investigated through tetrahydropyranylation and dehydropyranylation of a wide variety of alcohols and phenols at room temperature by changing the solvent medium from dichloromethane to methanol. Excellent yields, short reaction times, easy and quick isolation of the products and reusability of the catalyst are the main attractions of this method. The novel carbon catalyst holds great potential in the green chemical processes. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.05.025

文献信息

• NOVEL CYP-EICOSANOID DERIVATIVES
  申请人：MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

  公开号：US20170008918A1

  公开（公告）日：2017-01-12

  The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for C the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.

  本发明涉及一般式（I）的化合物，这些化合物是由细胞色素P450（CYP）酶从ω-3（n-3）多不饱和脂肪酸（PUFAs）产生的环氧代谢产物的类似物。本发明还涉及含有这些化合物中的一个或多个的组合物，以及利用这些化合物或组合物用于治疗或预防与炎症、增殖、高血压、凝血、免疫功能、病理性血管生成、心力衰竭和心律失常相关的疾病和症状。
• [EN] COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS<br/>[FR] COMPOSES ET COMPOSITIONS UTILISES COMME INHIBITEURS DE LA CATHEPSINE S
  申请人：NOVARTIS AG

  公开号：WO2006018284A1

  公开（公告）日：2006-02-23

  The present invention relates to the use of a 2-cyanopyrimidine compound of the formula (I), wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and , where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.

  本发明涉及使用式(I)的2-氰基嘧啶化合物，其中R1、R2、R3和X如规范和权利要求中定义的那样，以自由形式或盐形式，并在可能的情况下以互变异构形式，作为猫hepsin S活性的抑制剂。
• Indium triiodide catalysed one-step conversion of tetrahydropyranyl ethers to acetates with high selectivity
  作者：Brindaban C. Ranu、Alakananda Hajra

  DOI：10.1039/b100014b

  日期：——

  A very simple and efficient method has been developed for the chemoselective one-step conversion of tetrahydropyranyl ethers of primary alcohols to the corresponding acetates through an indium triiodide catalysed transesterification process in ethyl acetate.

  一种非常简单高效的方法被开发出来，可以通过在乙酸乙酯中以碘化铟为催化剂的转酯化过程，将初级醇的四氢吡喃醚选择性地一步转化为相应的醋酸酯。
• Highly selective one-pot conversion of THP and MOM ethers to acetates by indium triiodide-catalysed deprotection and subsequent transesterification by ethyl acetate
  作者：Brindaban C. Ranu、Alakananda Hajra

  DOI：10.1039/b104055n

  日期：——

  A simple and efficient method is developed for the chemoselective one-pot conversion of tetrahydropyranyl (THP) and methoxymethyl (MOM) ethers of primary alcohols to the corresponding acetates by indium triiodide-catalysed deprotection and subsequent acetylation by ethyl acetate through a transesterification process.

  我们开发了一种简单而高效的方法，通过铟三碘催化去保护和随后的醋酸乙酯转酯化过程，将初级醇的四氢吡喃基（THP）和甲氧基甲基（MOM）醚选择性地一锅转化为相应的醋酸酯。
• PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE PIPERIDINE COMPOUND
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2022782A1

  公开（公告）日：2009-02-11

  The present invention relates to a method for preparing a syn-form piperidine compound represented by general formula [I]: wherein, bold lines represent bonds in which substituents at positions 2 and 4 of a piperidine ring are in the syn configuration, and the other symbols have the same meaning as defined below, or a salt thereof, comprising: reducing a compound represented by general formula [II]: wherein, ring A represents an optionally substituted benzene ring, R2 represents a hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, and M represents an alkaline metal or hydrogen atom.

  本发明涉及一种制备由通用式[I]表示的同构吡啶化合物的方法：其中，粗线表示吡啶环的2位和4位取代基处于同构构象，其他符号的含义如下定义，或其盐，包括：还原由通用式[II]表示的化合物：其中，环A表示一个可选择取代的苯环，R2表示氢原子、可选择取代的羟基、可选择取代的氨基、可选择取代的烷基、取代的羰基或卤素原子，M表示碱金属或氢原子。