1,6-hexanediol dibenzoate | 22915-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,6-hexanediol dibenzoate
• 英文别名: 6-benzoyloxyhexyl benzoate
• CAS: 22915-73-7
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.392
• InChiKey: TYTTZVDFWCBYPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  己二氨基甲酸乙酯 在 sodium hydroxide 、 sodium nitrite 作用下， 生成 1,6-hexanediol dibenzoate
  参考文献：
  名称：

  Preparation and Reactions of Bis-diazoalkanes

  摘要：

  DOI：

  10.1021/ja01631a034

文献信息

• Solvent-free synthesis of symmetric methylene diesters <i>via</i> direct reaction of aromatic carboxylates with 1,<i>n</i>-dihaloalkanes
  作者：Lin Bai、Shenglong Ding、Xiaofang Ma

  DOI：10.1039/d1ra04814g

  日期：——

  An efficient methodology for the synthesis of symmetrical methylene diesters was developed through direct reaction of various aromatic carboxylates with 1,n-dihaloalkanes under solvent-free conditions. This strategy offers a high product yield, facile work-up and purification, and an environmentally friendly approach to obtain long-chain methylene carboxylate scaffolds with increased diversity.

  通过各种芳族羧酸盐与 1, n-二卤代烷烃在无溶剂条件下的直接反应，开发了一种合成对称亚甲基二酯的有效方法。该策略提供了高产率、简便的后处理和纯化，以及一种环境友好的方法来获得具有增加多样性的长链羧酸亚甲酯支架。
• Metal-free transesterification catalyzed by tetramethylammonium methyl carbonate
  作者：Manabu Hatano、Yuji Tabata、Yurika Yoshida、Kohei Toh、Kenji Yamashita、Yoshihiro Ogura、Kazuaki Ishihara

  DOI：10.1039/c7gc03858e

  日期：——

  tetramethylammonium methyl carbonate is effective as a catalyst for the chemoselective, scalable, and reusable transesterification of various esters and alcohols in common organic solvents. In situ-generated highly active species, tetramethylammonium alkoxides, can greatly avoid self-decomposition at ≤110 °C, and are reusable. In particular, chelating substrates, such as amino alcohols, diols, triols,

  不含环境的无金属碳酸四甲基铵甲酯可有效用作各种酯和醇在普通有机溶剂中的化学选择性，可扩展性和可重复使用的酯交换反应的催化剂。原位生成的高活性物质四甲基铵醇盐可大大避免在≤110°C时自分解，并可重复使用。特别地，可以使用使常规金属盐催化剂失活的螯合底物，例如氨基醇，二醇，三醇，糖衍生物，生物碱，α-氨基酸酯等。还展示了100克规模的生物柴油生产。
• Chemo- and Stereoselective Monobenzoylation of 1,2-Diols Catalyzed by Organotin Compounds
  作者：Fumiaki Iwasaki、Toshihide Maki、Osamu Onomura、Waka Nakashima、Yoshihiro Matsumura

  DOI：10.1021/jo991394j

  日期：2000.2.1

  acyclic diols, in particular 1,2-diols, were selectively monobenzoylated in good yields by the reaction with benzoyl chloride in the presence of a catalytic amount of dimethyltin dichloride and inorganic bases such as potassium carbonate. Furthermore, the method was successfully applied to a kinetic resolution of racemic 1-phenyl-1,2-ethanediol using a chiral organotin catalyst. The ee was dependent

  已经开发了一种新的简便的二醇单酰化方法。通过在催化量的二氯化二甲基锡和无机碱例如碳酸钾的存在下，通过与苯甲酰氯反应，以高收率选择性地将多种环状和无环二醇，特别是1,2-二醇选择性地单苯甲酰化。此外，该方法已成功地用于使用手性有机锡催化剂的外消旋1-苯基-1,2-乙二醇的动力学拆分。ee取决于碱的种类，作为添加剂的水和反应温度。
• Odd–Even Effect of Dopant Molecules on Clearing Temperatures of Nematic Liquid-crystal Phases
  作者：Keiki Kishikawa、Yuri Haga、Takahiro Inoue、Tomohiro Watanabe、Masahiro Takahashi、Shigeo Kohmoto

  DOI：10.1246/cl.2012.1465

  日期：2012.11.5

  Nematic liquid-crystal phases doped with the novel dopant compounds 1 (C6F5COO(CH)nOCOC6F5, n = 1–7) and 2 (C6H5COO(CH)nOCOC6H5, n = 1–7) showed an “opposite odd–even effect” on clearing temperatur...

  掺杂新型掺杂剂化合物 1（C6F5COO(CH)nOCOC6F5，n = 1-7）和 2（C6H5COO(CH)nOCOC6H5，n = 1-7）的向列液晶相显示出“相反的奇偶效应”清除温度...
• DBU-Based Dicationic Ionic Liquids Promoted Esterification Reaction of Carboxylic Acid with Primary Chloroalkane Under Mild Conditions
  作者：Yang Liu、Guijie Mao、Hongyan Zhao、Jinyi Song、Huatao Han、Zhuofei Li、Wenyi Chu、Zhizhong Sun

  DOI：10.1007/s10562-017-2184-4

  日期：2017.11

  dicationic ionic liquids with different anions were successfully synthesized by the reaction of DBU and 1, 6-dichlorohexane. Therein, the dicationic ionic liquid 1, 1′-(hexane-1, 6-diyl)bis(1, 8-diazabicyclo [5.4.0]undec-7-enium) dichlorine (IL-1) was successfully employed as an efficient catalyst in esterification reaction of carboxylic acids with primary chloroalkanes under mild conditions without any

  通过DBU与1,6-二氯己烷反应，成功合成了一系列具有不同阴离子的DBU基（DBU = 1, 8-二氮杂双环[5.4.0] undec-7-ene）双阳离子离子液体。其中，双阳离子离子液体 1, 1'-(己烷-1, 6-二基)双(1, 8-二氮杂双环 [5.4.0] undec-7-enium) 二氯 (IL-1) 被成功用作高效羧酸与伯氯烷烃在温和条件下进行酯化反应的催化剂，无需任何额外的碱性试剂。此外，优化的催化剂可以有效地重复使用5次，催化效果没有任何显着变化。改进后的协议不仅高效，而且绿色无污染。 图文摘要