N-hexadecyl-N-(2-methoxyethyl)-N,N-dimethylammonium bromide | 42474-91-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-hexadecyl-N-(2-methoxyethyl)-N,N-dimethylammonium bromide
• 英文别名: N,N-dimethyl-N-hexadecyl-N-(2-methoxy)ethylammonium bromide；C16EO1；N-(2-methoxyethyl)-N,N-dimethylhexadecan-1-ammonium bromide；hexadecyl-(2-methoxy-ethyl)-dimethyl-ammonium bromide；Hexadecyl-(2-methoxyethyl)-dimethylazanium;bromide
• CAS: 42474-91-9
• 化学式: Br*C₂₁H₄₆NO
• 分子量: 408.506
• InChiKey: VIWNWEXEXNSVPM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.19
• 重原子数：
  24
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴代十六烷 在 sodium hydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 72.0h， 生成 N-hexadecyl-N-(2-methoxyethyl)-N,N-dimethylammonium bromide
  参考文献：
  名称：

  头基大小或表面活性剂的亲水性：阳离子油包水微乳液中脂肪酶活性的主要调节剂。

  摘要：

  为了确定表面活性剂头基团大小在胶束酶学中的关键作用，估计了三种不同系列的具有不同头基团的表面活性剂在阳离子油包水（w / o）微乳液中的粘色杆菌（CV）脂酶的活性。尺寸和亲水性。通过随后用羟乙基（1-3，系列I），甲氧基乙基（4-6，系列II）和正丙基（7-9，系列III）将十六烷基三甲基溴化铵（CTAB）的三个甲基取代来制备不同的系列。 ）组。极性头的亲水性从系列I逐渐降低到系列III。有趣的是，发现相对于系列I的亲水性类似物，系列II表面活性剂的脂肪酶活性明显更高。此外，该活性对于系列I和III的互补类似物仍然几乎可比，尽管亲水性大不相同。明显地，对于系列I和III的可比较的表面活性剂，每个表面活性剂的头基面积几乎相似，但是对于系列II的表面活性剂明显更高。因此，脂肪酶的活性在很大程度上受表面活性剂头基团大小的调节，该表面活性剂在亲水性上起着主导作用。头基团大小的增加可能使酶获得灵活的

  DOI：

  10.1002/chem.200500244

文献信息

• ELECTROSPUN POLYMER NANOFIBERS WITH SURFACE ACTIVE QUATERNARY AMMONIUM SALT ANTIMICROBIALS
  申请人：Coneski Peter N.

  公开号：US20140221495A1

  公开（公告）日：2014-08-07

  A fiber having a polymeric matrix and a quarternary ammonium salt. The quarternary ammonium salt contains at least one aliphatic group and no aromatic groups, is not covalently incorporated into the polymeric matrix, and is present on both the surface and in the interior of the fiber. The fiber may be made by electrospinning a solution of the polymer and the quarternary ammonium salt.

  一种具有聚合物基质和季铵盐的纤维。季铵盐至少包含一个脂肪族基团而没有芳香族基团，不与聚合物基质共价结合，并同时存在于纤维的表面和内部。该纤维可以通过电纺聚合物和季铵盐的溶液制备而成。
• WO2007/44784
  申请人：——

  公开号：——

  公开（公告）日：——
• Relationship between surface concentration of amphiphilic quaternary ammonium biocides in electrospun polymer fibers and biocidal activity
  作者：Jeffrey G. Lundin、Peter N. Coneski、Preston A. Fulmer、James H. Wynne

  DOI：10.1016/j.reactfunctpolym.2014.02.004

  日期：2014.4

  Electrospinning was utilized to generate antimicrobial Nylon and polycarbonate fibers for potential applications including self-decontaminating fabrics, wound dressings, and filtration media. The effects of quaternary ammonium salt concentration on fiber morphology, diameter, and antimicrobial activity of the resulting fiber mats were investigated. Fibers were characterized utilizing scanning electron microscopy and X-ray photoelectron spectroscopy, while antimicrobial activity was evaluated against Staphylococcus aureus. The co-electrospinning of soluble quaternary ammonium biocides within polymeric solutions generated uniform fibers with diameters ranging from 91 to 278 nm for Nylon and 0.55-2.34 mu m for polycarbonate. Fiber morphology and diameter of the resulting fibers were shown to be dependent on polymer type and biocide concentration. A positive correlation between surface concentration of quaternary ammonium salts and antimicrobial activity was observed as fibers loaded with biocides exhibited up to a 7 log reduction of viable bacteria. Published by Elsevier B.V.
• Self-Decontaminating Surface Coatings and Articles Prepared Therefrom
  申请人：Rogers E. Martin

  公开号：US20080050410A1

  公开（公告）日：2008-02-28

  The present invention is directed toward a self-decontaminating surface coating, which when cured has a partially hydrophobic surface. The coating comprises a polymeric coating resin which, when cured, is hydrophilic. The coating also comprises a biocide, a germinating agent, and a hydrophobic micro/nano particulate material. The coating is suitable for application to ceramics, metals, and polymer substrates. Articles coated with the coating of the present invention are resistant to spores.
• US9241482B2
  申请人：——

  公开号：US9241482B2

  公开（公告）日：2016-01-26