1-(2-Phenylethyl)-1-prop-2-ynylhydrazine | 374688-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Phenylethyl)-1-prop-2-ynylhydrazine
• CAS: 374688-49-0
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: YRSPDBZZQRNQQV-UHFFFAOYSA-N

物化性质

• 沸点：
  303.6±35.0 °C(Predicted)
• 密度：
  1.046±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴丙炔 、 苯乙肼 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以84%的产率得到1-(2-Phenylethyl)-1-prop-2-ynylhydrazine
  参考文献：
  名称：

  Synthesis of N-propargylphenelzine and analogues as neuroprotective agents

  摘要：

  A series of N-1- and N-2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N-1- and N-2-propargylphenelzines. (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00549-2

文献信息

• Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
  作者：Lei Ling、Liana J. Urichuk、B.Duff Sloley、Ronald T. Coutts、Glen B. Baker、Jacqueline J. Shan、Peter K.T. Pang

  DOI：10.1016/s0960-894x(01)00549-2

  日期：2001.10

  A series of N-1- and N-2-propargylphenelzine derivatives and analogues (1-7) was synthesized. In addition to their activity as monoamine oxidase inhibitors, two of the compounds, N-1- and N-2-propargylphenelzines. (3 and 6), were found to be potent at preventing DSP-4-induced noradrenaline (NA) depletion in mouse hippocampus, suggesting that they have neuroprotective properties. (C) 2001 Elsevier Science Ltd. All rights reserved.