2-(4-chlorobenzyl)-4,4-dimethyl-2-oxazoline | 332095-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorobenzyl)-4,4-dimethyl-2-oxazoline
• 英文别名: 2-[(4-chlorophenyl)methyl]-4,4-dimethyl-5H-1,3-oxazole
• CAS: 332095-23-5
• 化学式: C₁₂H₁₄ClNO
• 分子量: 223.702
• InChiKey: DVQHENULEOCHAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-chlorobenzyl)-4,4-dimethyl-2-oxazoline 生成 4'-chlorophenyl(4,4-dimethyl-2-oxazolin-2-yl)ketone
  参考文献：
  名称：

  CLOUGH, J. M.;WORTHINGTON, P. A.;BEAUTEMENT, K.

  摘要：

  DOI：
• 作为产物：
  描述：

  对氯苯乙酸 、 2-氨基-2-甲基-1-丙醇 生成 2-(4-chlorobenzyl)-4,4-dimethyl-2-oxazoline
  参考文献：
  名称：

  CLOUGH, J. M.;WORTHINGTON, P. A.;BEAUTEMENT, K.

  摘要：

  DOI：

文献信息

• Substituted quinolinone-alkanecarboxylic acids and medicaments
  申请人：Byk Gulden Lomberg Chemische Fabrik Gesellschaft mit Beschrankter Haftung

  公开号：US04395414A1

  公开（公告）日：1983-07-26

  Quinolinone-alkanecarboxylic acids of the formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different and denote hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group with 1 to 4 carbon atoms, an amino group, a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or a nitro group, R.sup.4 and R.sup.5 are identical or different and denote a hydrogen atom, a halogen atom, an alkoxy group with 1 to 4 carbon atoms, a hydroxyl group, an amino group or a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or R.sup.4 and R.sup.5 together denote a methylenedioxy group bonded to two adjacent ring carbon atoms, and A denotes an alkylene group with 1 to 5 carbon atoms, and esters thereof with alkanols with 1 to 5 carbon atoms, and salts thereof with inorganic and organic bases are new compounds. They display a hyperglycaemic action in warm-blooded animals. Processes for the preparation of the new compounds are given.

  式I中的喹啉酮-烷基羧酸：##STR1## 其中R.sup.1，R.sup.2和R.sup.3相同或不同，表示氢原子，卤素原子，羟基，具有1至4个碳原子的烷氧基，氨基，二烷基氨基，具有1至4个碳原子的烷基基团或硝基；R.sup.4和R.sup.5相同或不同，表示氢原子，卤素原子，具有1至4个碳原子的烷氧基，羟基，氨基或二烷基氨基，具有1至4个碳原子的烷基基团，或R.sup.4和R.sup.5共同表示与两个相邻环碳原子键合的亚甲二氧基基团；A表示具有1至5个碳原子的烷基基团。新化合物为该类化合物的酯，其中烷醇具有1至5个碳原子，并且与无机和有机碱的盐。它们在恒温动物中显示出高血糖作用。给出了制备新化合物的过程。
• Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：EP0024638A1

  公开（公告）日：1981-03-11

  Quinolinone-alkanecarboxylic acids of the formula wherein R1, R2 and R' are identical or different and denote a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group with 1 to 4 carbon atoms, an amino group, a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or a nitro group, R4 and R5 are identical or different and denote a hydrogen atom, a halogen atom, an alkoxy group with 1 to 4 carbon atoms, a hydroxyl group, an amino group or a dialkylamino group, the alkyl radicals having 1 to 4 carbon atoms, or R4 and R5 together denote a methylenedioxy group bonded to two adjacent ring carbon atoms, and A denotes an alkylene group with 1 to 5 carbon atoms, and esters thereof with alkanols with 1 to 5 carbon atoms, and salts thereof with inorganic and organic bases are new compounds. They display a hyperglycaemic action in warm- blooded animals. Processes for the preparation of the new compounds are given.

  式中的喹啉酮-烷基羧酸 式中 R1、R2 和 R' 相同或不同，表示氢原子、卤素原子、羟基、1 至 4 个碳原子的烷氧基、氨基、二烷基氨基、1 至 4 个碳原子的烷基或硝基、 R4 和 R5 相同或不同，表示氢原子、卤素原子、1 至 4 个碳原子的烷氧基、羟基、氨基或二烷基氨基，这些烷基具有 1 至 4 个碳原子，或 R4 和 R5 共同表示键合到两个相邻环碳原子上的亚甲基二氧基，A 表示具有 1 至 5 个碳原子的亚烷基、 及其与具有 1 至 5 个碳原子的烷醇的酯类，以及其与无机碱和有机碱的盐类都是新化合物。它们对温血动物具有高血糖作用。本文给出了制备这些新化合物的工艺。
• Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0099165A1

  公开（公告）日：1984-01-25

  wherein R1 is hydrogen, alkyl, cycloalkyl, heterocyclyl, or aryl or aralkyl both optionally substituted with halogen, nitro, alkyl, haloalkyl, alkoxy, phenyl, phenoxy, halophenyl, or haloalkoxy; R2 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl or acyl; R3 and R4, which may be the same or different, are hydrogen, alkyl, alkenyl, or optionally substituted aryl; W is N or CH; X is -CO2R5, -CONR6R7, -CN, -CHO, 4,4-dimethyl-Δ2-oxazolin-2-yl, or 4,4,6-trimethyl-5,6-dihydro-1,3-oxazin-2-yl; R5, R6 and R7, which may be the same or different, are hydrogen, optionally substituted alkyl, optionally substituted aralkyl, alkenyl, or optionally substituted aryl; and their acid addition salts and metal complexes. The compounds have fungicidal activity and plant growth regulating activity.

  其中 R1 是氢、烷基、环烷基、杂环烷基或芳基或芳烷基，两者可任选被卤素、硝基、烷基、卤代烷基、烷氧基、苯基、苯氧基、卤代苯基或卤代烷氧基取代；R2 是氢、烷基、烯基、炔基、芳烷基或酰基；R3 和 R4 可以相同或不同，是氢、烷基、烯基或任选取代的芳基；W是N或CH；X是-CO2R5、-CONR6R7、-CN、-CHO、4,4-二甲基-Δ2-恶唑啉-2-基或4,4,6-三甲基-5,6-二氢-1,3-恶嗪-2-基；R5、R6和R7可以相同或不同，是氢、任选取代的烷基、任选取代的芳基、烯基或任选取代的芳基；以及它们的酸加成盐和金属络合物。这些化合物具有杀菌活性和植物生长调节活性。
• EISTETTER, K.;RAPP, E.;WOLF, H.
  作者：EISTETTER, K.、RAPP, E.、WOLF, H.

  DOI：——

  日期：——
• US4395414A
  申请人：——

  公开号：US4395414A

  公开（公告）日：1983-07-26