(S)-2-Thiophen-2-yl-propionic acid methyl ester | 126899-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (S)-2-Thiophen-2-yl-propionic acid methyl ester
• 英文别名: methyl (2S)-2-thiophen-2-ylpropanoate
• CAS: 126899-46-5
• 化学式: C₈H₁₀O₂S
• 分子量: 170.232
• InChiKey: FASSXLPWQJKPFP-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 α-methyl-α-(2-thienyl)malonic acid 生成 (R)-2-Thiophen-2-yl-propionic acid methyl ester 、 (S)-2-Thiophen-2-yl-propionic acid methyl ester
  参考文献：
  名称：

  Enzyme-mediated asymmetric decarboxylation of disubstituted malonic acids

  摘要：

  DOI：

  10.1021/ja00166a076

文献信息

• Amphiphilic pyridinium compounds, method of making and use thereof
  申请人：Pollard B. Harvey

  公开号：US20070105916A1

  公开（公告）日：2007-05-10

  The present invention is directed to the amphiphilic pyridinium compounds, such as for suppressing IL-8 secretion and production. The present invention further provides methods of making and using such compounds for the treatment of the IL-8 related diseases, such as cystic fibrosis.
• METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER
  申请人：Shiina Isamu

  公开号：US20140135520A1

  公开（公告）日：2014-05-15

  A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting a racemic carboxylic acid and a specific alcohol or phenol derivatives in a polar solvent having a dipole moment of 3.0 or higher in the presence of an acid anhydride and an asymmetric catalyst, esterifying one enantiomer of the racemic carboxylic acid at high selectivity, and increasing the amount of esterified carboxylic acid by racemizing the optically active carboxylic acid which is the other enantiomer not used in esterification.
• US7893094B2
  申请人：——

  公开号：US7893094B2

  公开（公告）日：2011-02-22
• US9315442B2
  申请人：——

  公开号：US9315442B2

  公开（公告）日：2016-04-19
• Enzyme-mediated asymmetric decarboxylation of disubstituted malonic acids
  作者：Kenji Miyamoto、Hiromichi Ohta

  DOI：10.1021/ja00166a076

  日期：1990.5