N.N-Dimethyl-O-isopropyl-thiocarbaminsaeureester | 24060-02-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代羰基化合物
• 英文名称: N.N-Dimethyl-O-isopropyl-thiocarbaminsaeureester
• 英文别名: Dimethylcarbamothioic acid, O-isopropyl ester；O-propan-2-yl N,N-dimethylcarbamothioate
• CAS: 24060-02-4
• 化学式: C₆H₁₃NOS
• 分子量: 147.241
• InChiKey: NOFGKMSNOXEHOX-UHFFFAOYSA-N

物化性质

• 沸点：
  228-230 °C
• 密度：
  1.004±0.06 g/cm3(Predicted)
• 保留指数：
  1131.3

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  sodium isopropylate 、 二甲氨基硫代甲酰氯 以 乙醚 、 异丙醇 为溶剂， 生成 N.N-Dimethyl-O-isopropyl-thiocarbaminsaeureester
  参考文献：
  名称：

  Walter,W.; Becker,R.F., Justus Liebigs Annalen der Chemie, 1969, vol. 725, p. 234 - 237

  摘要：

  DOI：

文献信息

• NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY
  申请人：Iikura Hitoshi

  公开号：US20100004233A1

  公开（公告）日：2010-01-07

  The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y 1 and Y 2 are selected from —N═ etc., Y 3 and Y 4 are selected from —CH═ etc., A is selected from sulfamide etc., R 1 is selected from hydrogen etc., and R 2 is selected from C 1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.

  本发明提供了一个由下式（1）所表示的化合物或其药学上可接受的盐： 其中，X选择自杂环芳基等，Y1和Y2选择自—N═等，Y3和Y4选择自—CH═等，A选择自磺酰胺等，R1选择自氢等，R2选择自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，并且在治疗细胞增殖性疾病，特别是癌症方面有用。本发明还提供了一种含有该化合物或盐作为活性成分的药物组合物。
• Novel Coumarin Derivative Having Antitumor Activity
  申请人：Iikura Hitoshi

  公开号：US20110092700A1

  公开（公告）日：2011-04-21

  The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y 1 and Y 2 are selected from —N═ etc., Y 3 and Y 4 are selected from —CH═ etc., A is selected from sulfamide etc., R 1 is selected from hydrogen etc., and R 2 is selected from C 1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.

  本发明提供一种由下式（1）或其药学上可接受的盐所表示的化合物：其中，X选自杂环芳基等；Y1和Y2选自—N═等；Y3和Y4选自—CH═等；A选自磺酰胺等；R1选自氢等；R2选自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，并可用于治疗细胞增殖性疾病，特别是癌症。本发明还提供一种含有该化合物或盐作为活性成分的制药组合物。
• p27 Protein Inducer
  申请人：Sakai Toshiyuki

  公开号：US20110009398A1

  公开（公告）日：2011-01-13

  The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from —N═ etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from —CH 2 — etc., and R 2 is selected from C 1-6 alkyl etc.

  本发明提供了一种p27蛋白诱导剂，其包含以下通式（11）所表示的化合物或其药学上可接受的盐作为活性成分：其中G1，G2，G3和G8各自独立地选择自—N═等，环G6选择自双价芳基等，A选择自氨基等，G4选择自氧等，G5选择自氧等，G7选择自—CH2—等，R2选择自C1-6烷基等。
• Compositions and Methods for the Isolation of Biologically Active Proteins
  申请人：Forman Henry J.

  公开号：US20100221809A1

  公开（公告）日：2010-09-02

  This invention is directed to compositions and methods for the isolation and further characterization of eukaryotic, mammalian, and/or human PC-PLC. In addition, the present invention discloses methods for the synthesis of an affinity chromatography resin for the isolation and purification of biologically active proteins, including eukaryotic PC-PLC.
• NUCLEOSIDES AND NUCLEOTIDES WITH 3'-HYDROXY BLOCKING GROUPS
  申请人：Illumina Cambridge Limited

  公开号：US20200216891A1

  公开（公告）日：2020-07-09

  Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or thiocarbamate 3′-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3′-OH blocking group for sequencing applications.