N-Boc-(R)-3-amino-2-methylpropionic acid succinimidyl ester | 431911-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-Boc-(R)-3-amino-2-methylpropionic acid succinimidyl ester
• 英文别名: N-Boc-α-(R)-Me-β-Ala-OSu；(2,5-dioxopyrrolidin-1-yl) (2R)-2-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 431911-34-1
• 化学式: C₁₃H₂₀N₂O₆
• 分子量: 300.312
• InChiKey: BUFGJHIIVHVSJP-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-Boc-(R)-3-amino-2-methylpropionic acid succinimidyl ester 、 (3-amino-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl phosphate 在 碳酸氢钠 、 三氟乙酸 作用下， 以 水 、 乙腈 为溶剂， 反应 1.5h， 以48%的产率得到(3-((R)-3-amino-2-methylpropanamido)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methyl phosphate
  参考文献：
  名称：

  Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities

  摘要：

  We have synthesized a series of 5'-phosphorylated and 5'-cytidylyl-(3'-5')-cytidylyl-(3'-5')-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.006

文献信息

• Cryptophycin compound
  申请人：——

  公开号：US20020065261A1

  公开（公告）日：2002-05-30

  The present invention provides antitumor methods, formulations, and compounds comprising a cryptophycin.

  本发明提供了包含一种隐花链霉素的抗肿瘤方法、配方和化合物。
• US6747021B2
  申请人：——

  公开号：US6747021B2

  公开（公告）日：2004-06-08
• Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities
  作者：Keigo Mizusawa、Kenji Abe、Shinsuke Sando、Yasuhiro Aoyama

  DOI：10.1016/j.bmc.2009.02.006

  日期：2009.3

  We have synthesized a series of 5'-phosphorylated and 5'-cytidylyl-(3'-5')-cytidylyl-(3'-5')-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system. (C) 2009 Elsevier Ltd. All rights reserved.