羟非那西丁 | 4665-04-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 羟非那西丁
• 英文名称: 2-Hydroxy-acetophenetidin
• 英文别名: 2-Hydroxy-phenacetin；Acetamide, N-(4-ethoxy-2-hydroxyphenyl)-；N-(4-ethoxy-2-hydroxyphenyl)acetamide
• CAS: 4665-04-7
• 化学式: C₁₀H₁₃NO₃
• mdl: MFCD00009092
• 分子量: 195.218
• InChiKey: CFLMLQJYYALAPD-UHFFFAOYSA-N

物化性质

• 沸点：
  399.1±32.0 °C(Predicted)
• 密度：
  1.209±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

文献信息

• Novel compounds for use in weight loss and appetite suppression in humans
  申请人：——

  公开号：US20040192669A1

  公开（公告）日：2004-09-30

  Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

  从单子叶植物中获得的含有苯酚分子的苯酚化合物，其中与氧含有基团，氮或另一个氧含有基团以及C1-C4烷氧基共价连接，或通过化学合成，已被发现可作为减肥剂、食欲抑制剂、情绪增强剂和关节炎、睡眠呼吸暂停、纤维肌痛、糖尿病和高血糖的辅助治疗剂。本发明的其他化学化合物可能包括苯并噁唑啉-环状羟基酰胺、内酰胺和相应的葡萄糖苷，这些化合物可能作为苯酚化合物的前体。本发明的苯酚化合物和苯酚化合物的前体，在适合人类治疗使用的浓度下，可以从单子叶植物中获得，例如在它们的早期生长状态下收获以获得最佳产量的玉米。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Method and composition for increasing reproduction in mammalian and avian species
  申请人：THE UNIVERSITY OF UTAH

  公开号：EP0070016A1

  公开（公告）日：1983-01-19

  Reproductive performance in mammalian and avian species is stimulated by administering an effective amount of one or more compounds of any of Formulas I, II or III, typically at the rate of 0.01 to 2 mg/kg/day: (I) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 4 or 5 ring position, n represents the integers 0, 1 or 2, and A represents -OH, -NH2 or where R' represents C1-C4 alkyl, or physiologically acceptable salts thereof; (11) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 5 or 6 ring position, and n represents one of the integers 0, 1 or 2; and (III) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 6 or 7 ring position, and n represents one of the integers 0, 1 or 2; or physiologically acceptable salts thereof. The active compounds are incorporated in novel feed concentrates and feed compositions or parenteral dosage forms or implants utilized according to the recited method.

  通过施用有效量的一种或多种配方 I、II 或 III 中的任何一种化合物，通常以 0.01 至 2 毫克/千克/天的剂量，可刺激哺乳动物和鸟类的繁殖性能： (I) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 4 或 5 环位置、 n 代表整数 0、1 或 2，以及 A 代表-OH、-NH2 或 其中 R' 代表 C1-C4 烷基、 或其生理上可接受的盐类； (11) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 5 或 6 环位置，且 n 代表 0、1 或 2 整数之一；以及 (III) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 6 或 7 环位置，且 n 代表 0、1 或 2 整数之一； 或其生理上可接受的盐类。 根据所述方法，将活性化合物加入新型饲料浓缩物和饲料组合物或非肠外剂型或植入物中。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans
  申请人：——

  公开号：US20040209877A1

  公开（公告）日：2004-10-21

  Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to preserve and/or augment innate immune defenses in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

  酚类化合物，其酚类分子上共价连接着一个含氧基团、一个氮或另一个含氧基团，以及一个 C 1 -C 4 烷氧基基团的酚类化合物，可从单子叶植物或通过化学合成获得，已被发现可保护和/或增强人类和动物的先天性免疫防御功能。本发明的其他化合物可包括苯并恶嗪环羟肟酸、内酰胺和相应的葡萄糖苷，它们可作为酚类化合物的前体。本发明的酚类化合物和酚类化合物前体，在适合人类和动物治疗使用的浓度下，可从单子叶植物（如玉米）中获得，这些植物处于早期生长状态，及时收获可获得最佳产量。

表征谱图