N-tert-butyl-4-ethynylaniline | 1374418-17-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-tert-butyl-4-ethynylaniline
• CAS: 1374418-17-3
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: AWZDAZLKUHUEGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-溴-10-碘基蒽 、 N-tert-butyl-4-ethynylaniline 在 copper(l) iodide 、 四(三苯基膦)钯 、 二异丙胺 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以45%的产率得到4-((10-bromoanthracen-9-yl)ethynyl)-N-(tert-butyl)aniline
  参考文献：
  名称：

  Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives

  摘要：

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.092
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 生成 N-tert-butyl-4-ethynylaniline
  参考文献：
  名称：

  Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives

  摘要：

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.092

文献信息

• BLOCK POLYMER, COMPOSITE OF METAL AND BLOCK POLYMER, AND DEVICE
  申请人：Sone Takeyuki

  公开号：US20090061255A1

  公开（公告）日：2009-03-05

  A composite having a metal substance bonded to a block polymer. The composite is capable of electric bonding via the metallic substance. A device in which a pair of electrodes are connected via a polymer chain of the block polymer. The block polymer has in at least a part thereof a block structure of a repeating unit that has in a side chain thereof an organic functional group for bonding to at least one of the metallic entities. The polymer main chain of the block structure has a helical shape. In the composite of a metal and the block polymer, a part of the block structure of the block polymer is bonded to the metal species. In the device having the block polymer and an electrode composed of the metallic substance, a part of the block structure of the block polymer is bonded to the metallic substance.
• Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
  作者：Yoshio Saito、Shigenori Miyamoto、Azusa Suzuki、Katsuhiko Matsumoto、Tsutomu Ishihara、Isao Saito

  DOI：10.1016/j.bmcl.2012.02.092

  日期：2012.4

  We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a-g). These fluorescent nucleosides exhibited distinctive fluorescence at 470-600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1-7.2 with a pK(a) of 6.1. Such pH-sensitive fluorescent nucleosides can be used as 'on-off' fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection. (C) 2012 Elsevier Ltd. All rights reserved.