2,5-Pyrrolidinedione, 1,1a(2)-[dithiobis(3,1-phenylenecarbonyloxy)]bis- | 497262-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5-Pyrrolidinedione, 1,1a(2)-[dithiobis(3,1-phenylenecarbonyloxy)]bis-
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxycarbonylphenyl]disulfanyl]benzoate
• CAS: 497262-14-3
• 化学式: C₂₂H₁₆N₂O₈S₂
• 分子量: 500.5
• InChiKey: FSNMKAQTCNHVRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  178
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Acylthiols and component thiol compositions as anti-hiv and anti-retroviral agents
  申请人：Inman K. John

  公开号：US20050020831A1

  公开（公告）日：2005-01-27

  Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.

  某些硫醇和酰硫醇化合物通过攻击必要病毒蛋白的高度保守的锌指区域来抑制逆转录病毒的生长。本文介绍了这些化合物、含有它们的组合物以及使用它们治疗逆转录病毒感染（如HIV）的方法。这些化合物还可用于制备由灭活的逆转录病毒（如HIV）组成的疫苗、预防这些逆转录病毒的传播以及检测逆转录病毒蛋白。
• ACYTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
  申请人：Inman John K.

  公开号：US20090247473A1

  公开（公告）日：2009-10-01

  Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are described. These compounds are also useful for preparation of vaccines comprised of inactivated retroviruses such as HIV, prevention of the transmission of such retroviruses, and detection of retroviral proteins.

  某些硫醇和酰硫醇化合物通过攻击必要病毒蛋白质高度保守的锌指区域来抑制逆转录病毒的生长。本文描述了这些化合物、含有它们的组合物以及使用它们治疗逆转录病毒感染（如HIV）的方法。这些化合物还可用于制备由灭活逆转录病毒（如HIV）组成的疫苗，预防这种逆转录病毒的传播以及检测逆转录病毒蛋白质。
• Nucleic acid amplification
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10329544B2

  公开（公告）日：2019-06-25

  In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming a reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of a reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer. The polymer can include a sieving agent and/or a diffusion-reducing agent.

  在一些实施例中，本教导提供了核酸扩增的方法，包括形成反应混合物，并将反应混合物置于适合核酸扩增的条件下。在一些实施方案中，核酸扩增方法包括将待扩增核酸置于部分变性条件下。在一些实施方案中，核酸扩增的方法包括在不使被扩增核酸完全变性的情况下进行扩增。在某些实施方案中，核酸扩增方法采用催化同源重组的酶和聚合酶。在某些实施方案中，核酸扩增方法可在单个反应容器中进行。在某些实施方案中，核酸扩增方法可在反应混合物的单一连续液相中进行，无需对反应混合物进行分隔或固定反应成分。在某些实施方案中，核酸扩增方法包括在等温扩增条件下，将至少一种多核苷酸扩增到表面上，可选择在有聚合物存在的情况下进行。聚合物可包括筛分剂和/或扩散减少剂。
• Matrix arrays and methods for making same
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US10738353B2

  公开（公告）日：2020-08-11

  A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.

  形成聚合物基质阵列的方法包括将水溶液注入孔阵列的孔中。水溶液包括聚合物前体。该方法还包括在井阵列上施加不相溶流体以隔离井阵列孔内的水溶液，并聚合隔离在井阵列孔内的聚合物前体以形成聚合物基质阵列。一种设备包括传感器阵列、与传感器阵列相对应的井阵列和布置在井阵列中的聚合物基质阵列。
• ACYLTHIOLS AND COMPONENT THIOL COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
  申请人：The Gov. of USA, as represented by the Secretary, Dept. of Health and Human services, National Institutes of Health

  公开号：EP1425262A1

  公开（公告）日：2004-06-09