4-((2-morpholinoethyl)amino)benzaldehyde | 1155372-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((2-morpholinoethyl)amino)benzaldehyde
• 英文别名: Benzaldehyde, 4-[[2-(4-morpholinyl)ethyl]amino]-；4-(2-morpholin-4-ylethylamino)benzaldehyde
• CAS: 1155372-89-6
• 化学式: C₁₃H₁₈N₂O₂
• 分子量: 234.298
• InChiKey: VIVKYJPEUHFVLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-((2-morpholinoethyl)amino)benzaldehyde 、 1-methyl-3-(4-tolyl)-2-selenoxoimidazolidine-4-on 在 哌啶 、 aluminum (III) chloride 作用下， 以 1,4-二氧六环 为溶剂， 以38 %的产率得到1-methyl-5-(4-((2-morpholinoethyl)amino)benzylidene)-2-selenoxo-3-(4-tolyl)imidazolin-4-one
  参考文献：
  名称：

  1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES

  摘要：

  本发明涉及1-烷基-5-亚芳基-2-硒代肟咪唑烷-4-酮及其衍生物，制备它们的方法，以及含有它们的用于预防、改善或治疗神经退行性疾病的组合物。具体而言，本发明的新型化合物——1-烷基-5-亚芳基-2-硒代肟咪唑烷-4-酮及其衍生物，可用于作为预防、改善或治疗神经退行性疾病的优良组合物。

  公开号：

  EP4183776A1

文献信息

• KR102475361
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS 6-ISOPROPYL-BENZÈNE-1,3-DIOLS SUBSTITUÉS EN POSITION 4 ET LEUR UTILISATION
  申请人：TOPOTARGET AS

  公开号：WO2009066060A2

  公开（公告）日：2009-05-28

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 4-substituted-6-isopropyl-benzene 1,3-diol compounds (referred to herein as IBD compounds), which, inter alia, inhibit heat shock protein 90 (HSP90) function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HSP90 function, and in the treatment of diseases and conditions that are mediated by HSP90, that are ameliorated by the inhibition of HSP90 function, etc., including proliferative conditions such as cancer, etc.
• 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES
  申请人：Duksung Women's University Industry-Academic Cooperation Foundation

  公开号：EP4183776A1

  公开（公告）日：2023-05-24

  The present invention relates to 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, a method for producing the same, and a composition for prevention, improvement or treatment of neurodegenerative disease containing the same. Specifically, 1-alkyl-5-arylidene-2-selenoxoimidazolidine-4-ons and derivatives thereof, which are novel compounds of the present invention, can be used as an excellent composition for prevention, improvement or treatment of neurodegenerative disease.

  本发明涉及1-烷基-5-亚芳基-2-硒代肟咪唑烷-4-酮及其衍生物，制备它们的方法，以及含有它们的用于预防、改善或治疗神经退行性疾病的组合物。具体而言，本发明的新型化合物——1-烷基-5-亚芳基-2-硒代肟咪唑烷-4-酮及其衍生物，可用于作为预防、改善或治疗神经退行性疾病的优良组合物。