4-methoxybenzyl 7-phenylacetamido-3-[(triphenylphosporanylidene) methyl]-3-cephem-4-carboxylate | 1070867-95-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 4-methoxybenzyl 7-phenylacetamido-3-[(triphenylphosporanylidene) methyl]-3-cephem-4-carboxylate
• 英文别名: (4-Methoxyphenyl)methyl 8-oxo-7-[(2-phenylacetyl)amino]-3-[(triphenyl-lambda5-phosphanylidene)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate；(4-methoxyphenyl)methyl 8-oxo-7-[(2-phenylacetyl)amino]-3-[(triphenyl-λ5-phosphanylidene)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 1070867-95-6
• 化学式: C₄₂H₃₇N₂O₅PS
• 分子量: 712.806
• InChiKey: ZVHJDCGRENOSOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-甲基噻唑-5-甲醛 、 4-methoxybenzyl 7-phenylacetamido-3-[(triphenylphosporanylidene) methyl]-3-cephem-4-carboxylate 以 丙醇 、 氯仿 为溶剂， 反应 24.0h， 生成 (4-methoxyphenyl)methyl 3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  参考文献：
  名称：

  [EN] PROCESS FOR SELECTIVE PREPARATION OF Z-ISOMER OF CEFDITOREN AND PHARMACEUTICALLY ACCEPTABLE SALTS AND ESTERS THEREOF
  [FR] PROCEDE DE PREPARATION SELECTIVE DE L'ISOMERE Z DE CEDFITORENE ET DE SES SELS ET ESTERS PHARMACEUTIQUEMENT ACCEPTABLES

  摘要：

  公开号：

  WO2005016936A3
• 作为产物：
  描述：

  GCLE 、 三苯基膦 在 sodium iodide 、 sodium hydroxide 作用下， 以 氯仿 、 水 为溶剂， 反应 4.0h， 生成 4-methoxybenzyl 7-phenylacetamido-3-[(triphenylphosporanylidene) methyl]-3-cephem-4-carboxylate
  参考文献：
  名称：

  [EN] PROCESS FOR SELECTIVE PREPARATION OF Z-ISOMER OF CEFDITOREN AND PHARMACEUTICALLY ACCEPTABLE SALTS AND ESTERS THEREOF
  [FR] PROCEDE DE PREPARATION SELECTIVE DE L'ISOMERE Z DE CEDFITORENE ET DE SES SELS ET ESTERS PHARMACEUTIQUEMENT ACCEPTABLES

  摘要：

  公开号：

  WO2005016936A3

文献信息

• Process for the preparation of 3-propenyl cephalosporin DMF solvate
  申请人：ORCHID CHEMICALS & PHARMACEUTICALS LIMITED

  公开号：US20040087786A1

  公开（公告）日：2004-05-06

  The present invention relates to an improved process for the preparation of 3-propenyl cephalosporin DMF solvate, more particularly, the present invention relates to an improved process for the preparation of cefprozil DMF solvate of the formula (I), which is useful for the preparation of cefprozil of the formula (XIV). 1

  本发明涉及一种改进的制备3-丙烯基头孢菌素DMF溶剂结晶体的方法，更具体地，本发明涉及一种改进的制备cefprozil DMF溶剂结晶体的方法，其化学式为(I)，该方法对于制备化学式为(XIV)的cefprozil非常有用。
• DERIVATIZED CEPHALOSPORINS
  申请人：Gladius Pharmaceuticals Corporation

  公开号：EP3441071A1

  公开（公告）日：2019-02-13

  Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.

  广谱β-内酰胺酶抑制剂。某些抑制剂除了抑制β-内酰胺酶外，还具有很强的抗生素活性。本发明的化合物设计成在β-内酰胺环裂解时产生活性分子，可使β-内酰胺酶失活。本发明还提供了制造β-内酰胺酶抑制剂的方法和具有这种抑制作用的β-内酰胺类抗生素。此外，还提供了用于治疗或预防细菌感染的药物组合物以及治疗此类感染的方法。
• Derivatized 3-styryl-cephalosporins
  申请人：Gladius Pharmaceuticals Corporation

  公开号：US11028103B2

  公开（公告）日：2021-06-08

  Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.

  广谱β-内酰胺酶抑制剂。某些抑制剂除了抑制β-内酰胺酶外，还具有很强的抗生素活性。本发明的化合物设计成在β-内酰胺环裂解时产生活性分子，可使β-内酰胺酶失活。本发明还提供了制造β-内酰胺酶抑制剂的方法和具有这种抑制作用的β-内酰胺类抗生素。此外，还提供了用于治疗或预防细菌感染的药物组合物以及治疗此类感染的方法。
• Derivatized 3-Styryl-Cephalosporins
  申请人：GLADIUS PHARMACEUTICALS CORPORATION

  公开号：US20160031906A1

  公开（公告）日：2016-02-04

  Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making betalactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
• US9975905B2
  申请人：——

  公开号：US9975905B2

  公开（公告）日：2018-05-22