2-α-hydroxybenzhydrylbenzimidazole | 1235-28-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-α-hydroxybenzhydrylbenzimidazole
• 英文别名: 1H-Benzimidazol-2-yl(diphenyl)methanol
• CAS: 1235-28-5
• 化学式: C₂₀H₁₆N₂O
• mdl: MFCD00959369
• 分子量: 300.36
• InChiKey: JGWSXCAXWPAUFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-α-hydroxybenzhydrylbenzimidazole 、 1-(chloromethyl)imidazole 在 sodium hydride 作用下， 生成 2-[imidazol-1-ylmethoxy(diphenyl)methyl]-1H-benzimidazole
  参考文献：
  名称：

  Hida; Robert; Luu-Duc, Il Farmaco, 1994, vol. 49, # 7-8, p. 489 - 492

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基-1H-苯并咪唑-1-胺 在 正丁基锂 、 氨 、 sodium 作用下， 反应 2.83h， 生成 2-α-hydroxybenzhydrylbenzimidazole
  参考文献：
  名称：

  Metallation of 1-dialkylaminobenzimidazoles

  摘要：

  DOI：

  10.1007/bf00531477

文献信息

• A Swift One-Pot Solvent-Free Synthesis of Benzimidazole Derivatives and Their Metal Complexes: Hydrothermal Treatment, Enzymatic Inhibition, and Solubilization Studies
  作者：M. B. Taj、A. Raheel、W. Alelwani、D. Hajjar、A. Makki、A. M. Alnajeebi、N. A. Babteen、S. A. Tırmizi、S. Noor

  DOI：10.1134/s107036322008023x

  日期：2020.8

  Three benzimidazole derivatives, 1-(1H-benzimidazol-2-yl)ethanol (HBE), 1H-benzimidazol-2-yl(diphenyl)methanol (BDM) and 1,2-bis(1H-benzimidazol-2-yl)ethane-1,2-diol (BHBED), have been synthesized following the one-pot rapid green protocol. Complexes of benzimidazole derivatives with six 3dtransition metals, Cu(II), Mn(II), Zn(II), Fe(II), Co(II), and Ni(II), have been synthesized by free hydrothermal method. The synthesized products have been characterized by FTIR,H-1, and(13)C NMR, and mass spectroscopy, and CHN analysis, and 2:1 ligand to metal stoichiometry has been confirmed. The synthesized ligands and metal complexes have been tested for antioxidant potential (DPPH), inhibitory activity including inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), alpha-glucosidase. Micellar solubilization of the metal complexes has been studied in sodium dodecyl sulphate (SDS) by UV-Vis spectroscopy and conductivity. The selected complexes of nickel, zinc and cobalt have demonstrated interaction with SDS, and the value of critical micellar concentration increased in all cases.
• Bistrzycki; Przeworski, Chemische Berichte, 1912, vol. 45, p. 3495
  作者：Bistrzycki、Przeworski

  DOI：——

  日期：——
• Heterocyclic carbanions. Synthesis of 2-substituted imidazole and benzimidazoles and of 3-substituted pyrazoles by lithiation of N-(dialkylamino)methyl heterocycles
  作者：A. R. Katritzky、Gordon W. Rewcastle、Wei Qiang Fan

  DOI：10.1021/jo00259a014

  日期：1988.11
• Formaldehyde: a reagent for the simultaneous protection of nucleophilic centers and the activation and stabilization of alternative locations to electrophilic attack. I. A new synthetic method for the 2-substitution of N-unsubstituted benzimidazoles: formaldehyde as a versatile protecting agent for heterocyclic NH
  作者：Alan R. Katritzky、Kunihiko Akutagawa

  DOI：10.1021/jo00273a032

  日期：1989.6
• Ooi, Hong Chin; Suschitzky, Hans, Journal of the Chemical Society. Perkin transactions I, 1982, # 12, p. 2871 - 2876
  作者：Ooi, Hong Chin、Suschitzky, Hans

  DOI：——

  日期：——