Phenol, 4-[(E)-[(4-hydroxyphenyl)imino]methyl]- | 3246-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Phenol, 4-[(E)-[(4-hydroxyphenyl)imino]methyl]-
• 英文别名: 4-(4-hydroxybenzylideneamino)phenol；4-{[(4-hydroxyphenyl)imino]methyl}phenol；N-(p-hydroxybenzylidene)-p-hydroxyaniline；N-p-hydroxybenzyliden-p-hydroxyanilin
• CAS: 3246-65-9；127521-42-0
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: LJMQHGKETUOVSG-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.82
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  对氨基苯酚 、 对羟基苯甲醛 以 水 为溶剂， 反应 2.0h， 以82%的产率得到Phenol, 4-[(E)-[(4-hydroxyphenyl)imino]methyl]-
  参考文献：
  名称：

  白藜芦醇亚胺类似物清除 DPPH、Galvinoxyl 和 ABTS 自由基

  摘要：

  白藜芦醇（3,5,4'-三羟基芪）是一种植物产生的植物抗毒素。白藜芦醇以其抗癌、抗病毒和抗氧化特性而闻名。我们制备了白藜芦醇（（羟苯基亚氨基甲基）酚类）的亚胺类似物并测试了它们的抗氧化活性。所有制备的白藜芦醇类似物都能够清除 2,2-二苯基-1-苦基肼 (DPPH)、加尔文氧基 (GOR) 和 2,2'-叠氮基-双(3-乙基苯并噻唑啉)-6-磺酸 (ABTS) 自由基。抗氧化活性效率与羟基的数量和位置相关。最有效的抗氧化剂是在其分子的亚苄基部分含有三个羟基的白藜芦醇类似物。这些结果为白藜芦醇类似物的化学结构和生物活性之间的关系提供了新的见解。

  DOI：

  10.3390/molecules21010127

文献信息

• Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells
  作者：Mohamed Ksila、Anne Vejux、Emmanuelle Prost-Camus、Philippe Durand、Imen Ghzaiel、Thomas Nury、Dorian Duprey、Smail Meziane、Olfa Masmoudi-Kouki、Norbert Latruffe、Taoufik Ghrairi、Michel Prost、Gérard Lizard、Dominique Vervandier-Fasseur

  DOI：10.3390/molecules27154713

  日期：——

  especially anti-tumoral and antioxidant activity. Among numerous resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting biological activities. In the present study, we synthesized a series of imine analogs of trans-resveratrol (seven aza-stilbenes) following an easy and low-cost procedure of green chemistry. The toxicity of synthesized aza-stilbenes, which is currently unknown

  反式白藜芦醇是一种天然多酚，具有多种生物学特性，尤其是抗肿瘤和抗氧化活性。在众多白藜芦醇衍生物中，具有亚胺结合的氮杂二苯乙烯显示出有趣的生物活性。在本研究中，我们按照简单且低成本的绿色化学程序合成了一系列反式白藜芦醇（七种氮杂芪）的亚胺类似物。目前未知的合成氮杂二苯乙烯的毒性在鼠神经元 N2a 细胞上进行了评估，相对于反式-白藜芦醇，通过考虑：通过用磺基罗丹明 101 染色评估的细胞密度；酯酶活性，这是细胞活力的标准，通过用荧光素二乙酸酯染色；和跨膜线粒体电位，已知在细胞死亡期间会降低，通过使用流式细胞术用 DiOC 6 (3) 染色。此外，抗氧化活性通过 KRL（Kit Radicaux Libres）测定、DPPH（2,2'-二苯基-1-苦基肼自由基）测定和 FRAP（铁还原抗氧化能力）测定进行量化。还使用了 PAOT（Pouvoir 抗氧化剂总分）评分。氮杂芪提供不同的细胞毒性和抗氧
• The antioxidant effect of imine resveratrol analogues
  作者：Jing Lu、Chang Li、Yun-Feng Chai、De-Yu Yang、Cui-Rong Sun

  DOI：10.1016/j.bmcl.2012.06.026

  日期：2012.9

  Twenty five Imine resveratrol analogues (IRAs) were synthesized, replacing the C=C bond in resveratrol with C=N bond, as well as substitution modifications on aromatic rings. Radical scavenging activities against DPPH, along with singlet oxygen quenching capacities were evaluated, and further confirmed using density functional theory calculations (DFT). It was found that IRAs bearing ortho-OH on B ring have better radical scavenging activities against DPPH than resveratrol, these compounds were also found to be effective O-1(2) quenchers. Theoretical studies on the reaction mechanism of these compounds with O-1(2) suggest that the 1,3-addition to a double bond with a -OH group with the formation of allylic hydroperoxide is the most probable reaction route. (C) 2012 Elsevier Ltd. All rights reserved.
• Carbonates of acetylenic alcohols
  申请人：NIPPON PAINT CO., LTD.

  公开号：EP0457334B1

  公开（公告）日：1994-08-10
• LASER-DECOMPOSABLE RESIN COMPOSITION AND PATTERN-FORMING MATERIAL USING THE SAME
  申请人：TAGUCHI Yoshinori

  公开号：US20080268371A1

  公开（公告）日：2008-10-30

  A laser-decomposable resin composition, includes: (A) a polymer compound containing a structure represented by formula (0) as a repeating unit in a main chain of the polymer compound: wherein R 1 represents H or a hydrocarbyl group which may have a substituent; and (B) a photo-latent or heat-latent catalyst, and a pattern-forming material, includes: a layer containing the laser-decomposable resin composition.
• SURFACE COATING PROCESSES AND USES OF SAME
  申请人：Haverty Donncha

  公开号：US20100211158A1

  公开（公告）日：2010-08-19

  The present application relates to processes for coating surfaces and provides a method of forming a coating on a surface. The method involves bombarding a surface with particles having sufficient energy to remove surface material. At the same time an aerosol is delivered to the surface. The cooperative action of the particles impinging on the surface and the presence of the aerosol contribute to the formation of a coating on the surface.