4-chlorophenoxazine | 56821-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 4-chlorophenoxazine
• 英文别名: 4-Chloro-10H-phenoxazine
• CAS: 56821-05-7
• 化学式: C₁₂H₈ClNO
• 分子量: 217.655
• InChiKey: FSIVCGKPJLLXGH-UHFFFAOYSA-N

物化性质

• 熔点：
  82-83 °C
• 沸点：
  344.6±41.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chlorophenoxazine 、 5-甲基-2-吡咯烷酮 生成 10-[5-n-BUTYL-1-(5-n-BUTYL-1-PYRROLIN-2-YL)-2-PYRROLIN-2-YL]PHENOXAZINE
  参考文献：
  名称：

  10-(Bis-pyrrolinyl) phenoxazines

  摘要：

  从苯并噻吩、苯并噁嗪和乙脒并吖啶衍生物的双吡咯烷衍生物组中选择的新型酰胺化合物可通过在三氯化磷的存在下将苯并噻吩、苯并噁嗪或乙脒并吖啶与吡咯烷酮反应而得到。苯并噻吩、苯并噁嗪或乙脒并吖啶也可以与2-氯-1-(1-吡咯烷-2-基)-2-吡咯烯烃基化以提供本发明的化合物。双吡咯烷衍生物的典型例子包括2-甲氧基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯-2-基]-苯并噻吩、10-[1-(1-吡咯烷-2-基)-2-吡咯烯-2-基]苯并噁嗪和9,9-二甲基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烯-2-基]乙脒并吖啶。这些酰胺化合物可用作利尿剂、平滑肌松弛剂和抗血栓形成剂。

  公开号：

  US04115571A1
• 作为产物：
  描述：

  吩噁嗪 在 正丁基锂 、 六氯乙烷 、 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.58h， 生成 4-chlorophenoxazine
  参考文献：
  名称：

  Regiospecific lithiation of phenoxazine ortho to the oxygen atom. Synthesis of 4-mono- and 4,6-disubstituted phenoxazine derivatives

  摘要：

  DOI：

  10.1021/jo00270a027

文献信息

• DOPANT FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC OPTOELECTRONIC DEVICE, AND DISPLAY DEVICE
  申请人：SAMSUNG SDI CO., LTD.

  公开号：US20180291264A1

  公开（公告）日：2018-10-11

  The present invention relates to: a dopant for an organic optoelectronic device, represented by chemical formula 1; an organic optoelectronic device including the dopant; and a display device.

  本发明涉及：一种用化学式1表示的有机光电器件的掺杂剂；包括该掺杂剂的有机光电器件；以及一种显示设备。
• 10-Imidoylacridans
  申请人：Mead Johnson & Company

  公开号：US03962252A1

  公开（公告）日：1976-06-08

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazine and imidoylacridan products are generally useful as smooth muscle relaxants.

  通过将可选取自三氟甲基、卤素、二卤代、烷基或烷氧基的苯氧噻嗪或吖啶与从酰胺和内酰胺中原位制备的亚胺卤反应，可以制备新型的10-亚胺基苯氧噻嗪和10-亚胺基吖啶。具体的实施例包括10-(5-甲基-1-吡咯烯-2-基)苯氧噻嗪和9,9-二甲基-10-(5-甲基-1-吡咯烯-2-基)吖啶。亚胺基苯氧噻嗪和亚胺基吖啶产品通常用作平滑肌松弛剂。
• Phenothiazines, phenoxazines and acridan bis-pyrrolinyl derivatives
  申请人：Mead Johnson & Company

  公开号：US03946004A1

  公开（公告）日：1976-03-23

  Novel amidine compounds selected from the group consisting of bis-pyrrolinyl derivatives of phenothiazines, phenoxazines and acridans are obtained by reacting a phenothiazine, phenoxazine or acridan with a pyrrolidinone in the presence of phosphorus oxychloride. The phenothiazine, phenoxazine, or acridan can also be alkylated with 2-chloro-1-(1-pyrrolin-2-yl)-2-pyrroline to provide compounds of the invention. Typical examples of bis-pyrrolinyl derivatives are 2-methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]-pheno thiazine, 10-[1-(1-pyrrolin-2-yl)-2-pyrrolin-2-yl]phenoxazine, and 9,9-dimethyl-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-yl)-2-pyrrolin-2-yl]acr idan. The amidine compounds are useful as diuretics, smooth muscle relaxants and antithrombogenic agents.

  从苯并噻嗪，苯并噁嗪和乙酰基蒽中选择的双吡咯烷衍生物中选出新型的氨基咪啉化合物。在磷酸氧氯化物的存在下，将苯并噻嗪，苯并噁嗪或乙酰基蒽与吡咯酮反应即可得到该化合物。苯并噻嗪，苯并噁嗪或乙酰基蒽也可以与2-氯-1-(1-吡咯烷-2-基)-2-吡咯烷烷基化，以提供本发明的化合物。双吡咯烷衍生物的典型例子是2-甲氧基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烷-2-基]-苯并噻嗪，10-[1-(1-吡咯烷-2-基)-2-吡咯烷-2-基]苯并噁嗪和9,9-二甲基-10-[5-甲基-1-(5-甲基-1-吡咯烷-2-基)-2-吡咯烷-2-基]乙酰基蒽。该氨基咪啉化合物可用作利尿剂，平滑肌松弛剂和抗血栓形成剂。
• Smooth muscle relaxant process employing 10-imidoylphenoxazines
  申请人：Mead Johnson & Company

  公开号：US04046891A1

  公开（公告）日：1977-09-06

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.

  小说10-咪唑基苯氧噻嗪和10-咪唑基蒽醌是通过将具有三氟甲基、卤素、二卤代、烷基或烷氧等可选取代基的苯氧噻嗪或蒽醌与由酰胺和内酰胺在原位制备的咪唑酰卤反应制备而成。示例包括10-(5-甲基-1-吡咯烷-2-基)苯氧噻嗪和9,9-二甲基-10-(5-甲基-1-吡咯烷-2-基)蒽醌。咪唑基苯氧噻嗪和咪唑基蒽醌产品通常用作平滑肌松弛剂。
• Smooth muscle relaxant employing 10-imidoylacridans
  申请人：Mead Johnson & Company

  公开号：US04094981A1

  公开（公告）日：1978-06-13

  Novel 10-imidoylphenoxazines and 10-imidoylacridans are prepared by reacting a phenoxazine or acridan having optional substituents selected from the group consisting of trifluoromethyl, halogen, dihalogen, alkyl or alkoxy with an imidoyl halide prepared in situ from amides and lactams. Illustrative embodiments are 10-(5-methyl-1-pyrrolin-2-yl)phenoxazine and 9,9-dimethyl-10-(5-methyl-1-pyrrolin-2-yl)acridan. The imidoylphenoxazines and imidoylacridan products are generally useful as smooth muscle relaxants.

  小说10-咪唑基苯氧嗪和10-咪唑基蒽醌是通过将具有可选取代基的苯氧嗪或蒽醌与在位制备的酰亚胺卤化物反应而制备的，所述可选取代基选择自三氟甲基，卤素，二卤代，烷基或烷氧基。示例包括10-（5-甲基-1-吡咯烷-2-基）苯氧嗪和9,9-二甲基-10-（5-甲基-1-吡咯烷-2-基）蒽醌。咪唑基苯氧嗪和咪唑基蒽醌产品通常用作平滑肌松弛剂。