1-formylphenoxazine | 1918-34-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1-formylphenoxazine
• 英文别名: phenoxazine-1-aldehyde；Phenoxazin-1-carboxaldehyd；1-Formyl-phenoxazin；10H-phenoxazine-1-carbaldehyde；10H-phenoxazine-1-carbaldehyde
• CAS: 1918-34-9
• 化学式: C₁₃H₉NO₂
• 分子量: 211.22
• InChiKey: XJOZNXRXYZLUPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吩噁嗪 在 正丁基锂 、 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 1-formylphenoxazine
  参考文献：
  名称：

  Katritzky, Alan R.; Miguel, Luis M. Vazques de; Rewcastle, Gordon W., Heterocycles, 1987, vol. 26, # 12, p. 3135 - 3140

  摘要：

  DOI：

文献信息

• NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE
  申请人：Okano Akihiro

  公开号：US20120157459A1

  公开（公告）日：2012-06-21

  [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR 7 —; and R 1 to R 7 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

  提供一个以新型化合物作为活性成分的GPR40激活剂，该化合物具有GPR40激动剂作用，该化合物的盐，该盐或化合物的溶剂合物，或者类似物，尤其是胰岛素分泌促进剂以及对糖尿病、肥胖症或其他疾病的预防及/或治疗剂。[解决该问题的方法] 公式(I)的化合物：（其中n为0至2；p为0至4；j为0至3；k为0至2；环A是一个芳基团，可选择性被L取代或是一个杂环团，可选择性被L取代；环B是一个苯环、一个吡啶环或一个嘧啶环；X是O，S，—NR7—；R1至R7是特定基团），该化合物的盐，或该盐或化合物的溶剂合物。
• NOVEL ARYL UREA DERIVATIVE
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：EP2518064A1

  公开（公告）日：2012-10-31

  There is a need for FAAH inhibitors capable of oral administration and having excellent efficacy, particularly agents for the prevention and treatment of pain. Disclosed are novel arylurea compounds represented by formula (I), salts or solvates thereof, and pharmaceutical compositions comprising the same as an active ingredient. The pharmaceutical composition is used primarily for FAAH inhibitors, or agents for prevention and treatment of pain.

  需要具有口服能力且具有出色疗效的FAAH抑制剂，特别是用于预防和治疗疼痛的药物。揭示了由式(I)表示的新型芳基脲类化合物，其盐或溶剂，以及包含其作为活性成分的药物组合物。该药物组合物主要用于FAAH抑制剂，或用于预防和治疗疼痛的药物。
• Heterocyclic compound having oxime group
  申请人：Yoshida Ichiro

  公开号：US20050227959A1

  公开（公告）日：2005-10-13

  The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the General Formula (I) [where R 1 and R 2 independently represent a C 1-6 alkyl group and the like that may have a hydrogen atom or a substituent; R 3 represents a C 1-6 alkyl group and the like that may have a substituent; R 4 and R 5 independent represents a hydrogen atom or a C 1-6 alkyl group and the like that may have a substituent; R 6 represents a hydrogen atom and the like; W represents —SO 2 — and the like; and X represents a sulphur atom and the like.]or a salt thereof, or a hydrate thereof.

  本发明提供了一种对STAT6激活具有优异抑制活性且对过敏疾病有效的化合物及其药物组合物。根据本发明，公开了由通式（I）表示的化合物[其中R1和R2独立地表示可能具有氢原子或取代基等的C1-6烷基基团；R3表示可能具有取代基的C1-6烷基基团等；R4和R5独立地表示可能具有取代基的氢原子或C1-6烷基基团等；R6表示氢原子等；W表示—SO2—等；X表示硫原子等]或其盐或水合物。
• Cyclohepta[<i>b</i>][1,4]benzoxazines 3. The Reaction of 6-Bromocyclohepta[<i>b</i>][1,4]benzoxazine with<i>o</i>-Aminophenol
  作者：Tetsuo Nozoe、Harue Okai、Hidetsugu Wakabayashi、Sumio Ishikawa

  DOI：10.1246/bcsj.62.2307

  日期：1989.7

  The reaction of 6-bromocyclohepta[b][1,4]benzoxazine (19) and o-aminophenol (3) was studied and compared with that of 3-bromo-2-methoxytropone (2) with 3. 14H-[1,4]Benzoxazino[3′,2′:3,4]cyclohepta[1,2-b][1,4]benzoxazine, 10-(o-hydroxyanilino)cyclohepta[b][1,4]benzoxazine (D), 1- and 4-formylphenoxazines and their Schiff bases (C and X) were obtained in very good yields by modifying the conditions of the reaction of 19 with 3. Structures of D, C, and their isomers were determined and the possible reaction pathways for the formation of various products are discussed.

  研究了6-溴环七苯并[1,4]苯并噁嗪（19）与邻氨基酚（3）的反应，并与3-溴-2-甲氧基脱丙酮（2）与3的反应进行了比较。通过修改19与3的反应条件，成功获得了14H-[1,4]苯并噁嗪[3′,2′:3,4]环七[1,2-b][1,4]苯并噁嗪、10-(邻羟基苯胺基)环七[1,4]苯并噁嗪（D）、1-和4-羰基苯噁嗪及其施夫碱（C和X），产率非常可观。确立了D、C及其异构体的结构，并探讨了各种产物形成的可能反应路径。
• NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE
  申请人：Okano Akihiro

  公开号：US20120220772A1

  公开（公告）日：2012-08-30

  [Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is a specific cyclic group; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is —CH 2 —, O, —S(O) i — (i is 0 to 2), or —NR 7 —; R 1 to R 6 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

  提供一种GPR40激活剂，其作为活性成分具有一种具有GPR40激动剂作用的新化合物，该化合物的盐、盐或化合物的溶剂或类似物，特别是一种胰岛素分泌促进剂以及预防和/或治疗糖尿病、肥胖或其他疾病的药物。 通过以下公式(I)的化合物解决问题： （其中p为0至4；j为0至3；k为0至2；环A为特定的环状基团；环B为苯环、吡啶环或嘧啶环；X为—CH2—、O、—S(O)i—（i为0至2）或—NR7—；R1至R6为特定的基团），该化合物的盐或盐的溶剂。