Propanoic acid, 2-chloro-3-(phenylmethoxy)-, potassium salt (1:1) | 138666-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Propanoic acid, 2-chloro-3-(phenylmethoxy)-, potassium salt (1:1)
• CAS: 138666-92-9
• 化学式: C10H11ClKO3
• 分子量: 253.74
• InChiKey: YJWUCTSBPRQAID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 储存条件：
  室温

文献信息

• Process for the preparation of contrast agents
  申请人：BRACCO IMAGING S.p.A.

  公开号：EP1762563A1

  公开（公告）日：2007-03-14

  The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

  本发明涉及一种通过在适当的烷基化剂和碱存在下发生羧甲基化反应来制备式(I)化合物的方法，无需监测反应环境的pH。式(I)化合物是制备MRI技术的诊断造影剂的有用中间体。
• Process for the Preparation of Contrast Agents
  申请人：Ceragioli Silvia

  公开号：US20090118537A1

  公开（公告）日：2009-05-07

  The present invention refers to a process for preparing a compound of formula (I) through a carboxymethylation reaction occurring in the presence of a suitable alkylating agent and of a base, without the need of monitoring the pH of the reaction environment. The compound of formula (I) is a useful intermediate in the preparation of diagnostic contrast agents for MRI techniques.

  本发明涉及一种制备式(I)化合物的过程，该过程通过在适当的烷基化剂和碱的存在下发生羧甲基化反应，而无需监测反应环境的pH值。式(I)化合物是MRI技术诊断对比剂制备中有用的中间体。
• A PROCESS FOR THE PREPARATION OF 4-CARBOXY- 5,8,11- TRIS(CARBOXYMETHYL)- 1-PHENYL- 2-OXA- 5,8,11- TRIAZATRIDECAN- 13-OIC ACID
  申请人：Bracco Imaging S.p.A.

  公开号：EP1095009B1

  公开（公告）日：2005-06-15
• PROCESS FOR THE PREPARATION OF CONTRAST AGENTS
  申请人：BRACCO IMAGING S.p.A.

  公开号：EP1948590B1

  公开（公告）日：2010-08-18
• A process for the preparation of 2-chloro-3-(phenylmethoxy)propionic acid potassium salt
  申请人：BRACCO IMAGING S.p.A.

  公开号：EP1588998B1

  公开（公告）日：2011-11-30