1-[4-(8-Methyl-2,8-diazaspiro[4.5]decan-2-yl)phenyl]-4-phenylmethoxypyridin-2-one | 1032157-88-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-[4-(8-Methyl-2,8-diazaspiro[4.5]decan-2-yl)phenyl]-4-phenylmethoxypyridin-2-one
• CAS: 1032157-88-2
• 化学式: C₂₇H₃₁N₃O₂
• 分子量: 429.562
• InChiKey: UGFINEWODOOIBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  36
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 1-[4-(2,8-Diazaspiro[4.5]decan-2-yl)phenyl]-4-phenylmethoxypyridin-2-one 在 5%-palladium/activated carbon 噻吩 作用下， 以 甲醇 、 diisopropyether 为溶剂， 以78%的产率得到1-[4-(8-Methyl-2,8-diazaspiro[4.5]decan-2-yl)phenyl]-4-phenylmethoxypyridin-2-one
  参考文献：
  名称：

  WO2008/68265

  摘要：

  公开号：

文献信息

• NOVEL SUBSTITUTED DIAZA SPIRO PYRIDINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
  申请人：Janssen Pharmaceutica NV

  公开号：EP2102208B1

  公开（公告）日：2014-04-23
• NOVEL SUBSTITUTED DIAZA-SPIRO-PYRIDINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES
  申请人：Andres-Gil Jose Ignacio

  公开号：US20100035909A1

  公开（公告）日：2010-02-11

  The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
• US8158643B2
  申请人：——

  公开号：US8158643B2

  公开（公告）日：2012-04-17
• [EN] NOVEL SUBSTITUTED DIAZA SPIRO PYRIDINONE DERIVATIVES FOR USE IN MCH-1 MEDIATED DISEASES<br/>[FR] NOUVEAUX DÉRIVÉS DE DIAZA-SPIRO-PYRIDINONE SUBSTITUÉS POUR UNE UTILISATION DANS DES MALADIES À MÉDIATION PAR MCH-1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2008068265A1

  公开（公告）日：2008-06-12

  [EN] The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in Claim 1. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of psychiatric disorders, including but not limited to anxiety, eating disorders, mood disorders, such as bipolar disorders and depression, psychoses, such as schizophrenia, and sleeping disorders; obesity; diabetes; sexual disorders and neurological disorders.
  [FR] La présente invention porte sur des dérivés de diaza-spiro-pyridinone substitués par aryle et hétéroaryle, ayant une activité d'hormone de concentration en mélanine (MCH) antagoniste, en particulier une activité MCH-1, selon la Formule générale (I), sur un sel d'addition avec les acides ou les bases pharmaceutiquement acceptables de ceux-ci, une forme de N-oxyde de ceux-ci ou un sel d'ammonium quaternaire de ceux-ci, les variables étant définies dans la revendication 1. L'invention concerne en outre leur préparation, des compositions les comprenant et leur utilisation en tant que médicament. Les composés selon l'invention sont utiles pour la prévention et/ou le traitement de troubles psychiatriques, comprenant, mais sans y être limités, l'anxiété, les troubles de l'alimentation, les troubles de l'humeur, tels que les troubles bipolaires et la dépression, les psychoses, telles que la schizophrénie, et les troubles du sommeil; l'obésité; le diabète; les troubles sexuels et les troubles neurologiques.
• WO2008/68265
  申请人：——

  公开号：——

  公开（公告）日：——