carbamoylimino-acetic acid | 592-18-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: carbamoylimino-acetic acid
• 英文别名: Carbamoylimino-essigsaeure；(2E)-2-carbamoyliminoacetic acid
• CAS: 592-18-7
• 化学式: C₃H₄N₂O₃
• 分子量: 116.076
• InChiKey: XVUFGANHYPKKGB-ORCRQEGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  carbamoylimino-acetic acid 在 chromium(III) oxide 、 硫酸 作用下， 生成 仲班酸
  参考文献：
  名称：

  Biltz; Kobel, Chemische Berichte, 1921, vol. 54, p. 1809

  摘要：

  DOI：
• 作为产物：
  描述：

  海因 在 水 、 溴 作用下， 生成 carbamoylimino-acetic acid
  参考文献：
  名称：

  Siemonsen, Justus Liebigs Annalen der Chemie, 1904, vol. 333, p. 135

  摘要：

  DOI：

文献信息

• Intralesional Cidofovir Therapy for Laryngeal Papilloma in an Adult Cohort
  作者：Steven Bielamowicz、Vicente Villagomez、Sheila V. Stager、William R. Wilson

  DOI：10.1097/00005537-200204000-00019

  日期：2002.4

  AbstractObjectives To confirm the safety and efficacy of intralesional cidofovir in the management of laryngeal papilloma and to identify variables that correlate with number of injections needed to achieve remission.Study Design An open‐trial prospective evaluation of the efficacy of intralesional cidofovir in subjects with laryngeal papilloma.Methods Fourteen adult subjects with biopsy‐proven laryngeal papilloma were enrolled in a treatment study of intralesional cidofovir. Preprotocol disease duration ranged from 1 to 30 years with a mean duration of 7 years. Subjects received monthly injections of cidofovir with a maximum dose of 37.5 mg per injection in 6 cc saline (6.25 mg/mL). Injections were repeated until no papilloma could be visually identified during an intraoperative evaluation. After disease remission was achieved, subjects received an additional injection. All injections occurred during suspension microlaryngoscopy.Results All subjects have achieved disease remission using an injection‐only treatment protocol. No additional laryngeal scarring or systemic toxicity was identified. On average, 6 injections were required to achieve remission. Preprotocol disease duration and anatomical staging correlated positively with the number of injections required for disease remission.Conclusions Intralesional injection of cidofovir is an excellent treatment option with limited local and systemic toxicities. The injection therapy regimen requires perseverance from both patient and surgeon. Remission of disease can be achieved in adults with laryngeal papilloma.
• Siemonsen, Justus Liebigs Annalen der Chemie, 1904, vol. 333, p. 135
  作者：Siemonsen

  DOI：——

  日期：——
• Biltz; Kobel, Chemische Berichte, 1921, vol. 54, p. 1809
  作者：Biltz、Kobel

  DOI：——

  日期：——