1-[(2-Methyl-3-phenylprop-2-enylidene)amino]-3-phenylthiourea | 479364-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(2-Methyl-3-phenylprop-2-enylidene)amino]-3-phenylthiourea
• CAS: 479364-29-9
• 化学式: C₁₇H₁₇N₃S
• 分子量: 295.408
• InChiKey: YDNLPOVPDBPEST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硫代异氰酸苯酯 、 α-甲基肉桂醛 、 肼 以 甲醇 为溶剂， 反应 24.0h， 以52%的产率得到1-[(2-Methyl-3-phenylprop-2-enylidene)amino]-3-phenylthiourea
  参考文献：
  名称：

  One-pot and catalyst-free synthesis of thiosemicarbazones via multicomponent coupling reactions

  摘要：

  A novel and efficient procedure for the synthesis of thiosemicarbazones has been achieved via a multi-component and catalyst-free reaction of phenyl or p-chlorophenyl isothiocyanate, hydrazine, and aldehydes or ketones. The method afforded 20 thiosemicarbazones in good yields and short reaction time. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.134

文献信息

• One-pot and catalyst-free synthesis of thiosemicarbazones via multicomponent coupling reactions
  作者：Silvio Cunha、Tiago Lima da Silva

  DOI：10.1016/j.tetlet.2009.02.134

  日期：2009.5

  A novel and efficient procedure for the synthesis of thiosemicarbazones has been achieved via a multi-component and catalyst-free reaction of phenyl or p-chlorophenyl isothiocyanate, hydrazine, and aldehydes or ketones. The method afforded 20 thiosemicarbazones in good yields and short reaction time. (c) 2009 Elsevier Ltd. All rights reserved.