2-phenylmethoxy-N-(6-phenylmethoxy-9-propylpurin-2-yl)acetamide | 1026568-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-phenylmethoxy-N-(6-phenylmethoxy-9-propylpurin-2-yl)acetamide
• CAS: 1026568-67-1
• 化学式: C₂₄H₂₅N₅O₃
• 分子量: 431.494
• InChiKey: CWBQFQSAONVXPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-phenylmethoxy-N-(6-phenylmethoxy-9-propylpurin-2-yl)acetamide 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-Benzyloxy-N-(6-oxo-9-propyl-6,9-dihydro-1H-purin-2-yl)-acetamide
  参考文献：
  名称：

  Convenient synthesis of 2,9-disubstituted guanines mediated by solid-supported reagents

  摘要：

  A novel application has been developed to separate regioisomers chemoselectively using a solid-supported reagent. An N7/N9 purine regioisomer mixture was purified using aluminum oxide/H+ to provide the N9 isomer selectively as a parallel or high-throughput format (chemoselective high-throughput purification). 2,9-Disubstituted guanines were conveniently prepared by this new method in conjunction with solid-supported reagents. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00466-4
• 作为产物：
  描述：

  O-6-苄基鸟嘌呤 在 polymeric BEMP 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 2-phenylmethoxy-N-(6-phenylmethoxy-9-propylpurin-2-yl)acetamide
  参考文献：
  名称：

  Convenient synthesis of 2,9-disubstituted guanines mediated by solid-supported reagents

  摘要：

  A novel application has been developed to separate regioisomers chemoselectively using a solid-supported reagent. An N7/N9 purine regioisomer mixture was purified using aluminum oxide/H+ to provide the N9 isomer selectively as a parallel or high-throughput format (chemoselective high-throughput purification). 2,9-Disubstituted guanines were conveniently prepared by this new method in conjunction with solid-supported reagents. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00466-4

文献信息

• Convenient synthesis of 2,9-disubstituted guanines mediated by solid-supported reagents
  作者：Warren McComas、Li Chen、Kyungjin Kim

  DOI：10.1016/s0040-4039(00)00466-4

  日期：2000.5

  A novel application has been developed to separate regioisomers chemoselectively using a solid-supported reagent. An N7/N9 purine regioisomer mixture was purified using aluminum oxide/H+ to provide the N9 isomer selectively as a parallel or high-throughput format (chemoselective high-throughput purification). 2,9-Disubstituted guanines were conveniently prepared by this new method in conjunction with solid-supported reagents. (C) 2000 Elsevier Science Ltd. All rights reserved.