pyridine-3-carboxylic acid sulfate | 64030-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: pyridine-3-carboxylic acid sulfate
• 英文别名: nicotinic acid sulfate；Nicotinium hydrogen sulfate；hydrogen sulfate;pyridin-1-ium-3-carboxylic acid
• CAS: 64030-04-2
• 化学式: C₆H₅NO₂*H₂O₄S
• 分子量: 221.191
• InChiKey: FSSOYPTUNGNSQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.13
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  烟酸 在 硫酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以100%的产率得到pyridine-3-carboxylic acid sulfate
  参考文献：
  名称：

  吡啶基布朗斯台德酸性离子液体作为高效催化剂用于一锅法合成二氢嘧啶酮

  摘要：

  摘要 在这项工作中，报道了 3-羧基吡啶鎓硫酸氢盐 ([Hcpy]HSO4) 作为一种新的 Brønsted 酸性离子液体的合成和表征。这种可重复使用、廉价且绿色的催化剂用于 1,3-二羰基化合物、芳香醛和尿素或硫脲的一锅缩合反应，以合成相应的 3,4-二氢嘧啶-2(1H)-酮。反应在无溶剂和绿色条件下进行。该程序在很短的反应时间内以极好的收率得到了产物。图形概要

  DOI：

  10.1080/00397911.2010.523488
• 作为试剂：
  描述：

  对氨基苯甲酸 在 pyridine-3-carboxylic acid sulfate 、 sodium nitrite 、 sodium iodide 作用下， 以 水 为溶剂， 反应 0.33h， 以85%的产率得到4-碘苯甲酸
  参考文献：
  名称：

  Application of [Hcpy]HSO₄ Brönsted Acidic Ionic Liquid for the Synthesis of Aryl Iodides from Aromatic Amines

  摘要：

  DOI：

  10.1080/00304948.2011.582384

文献信息

• Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions
  申请人：——

  公开号：US20040092482A1

  公开（公告）日：2004-05-13

  This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as &agr;-(Alpha) Hydroxy Acids (AHA), &bgr;-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

  本发明涉及原位制备各种羟基酸（HA）的衍生物，如&agr;-（α）羟基酸（AHA）、&bgr；-(β)羟基酸 (BHA)、聚羟基酸 (PHA) 与某些对皮肤有益的有机杂原子基团的衍生物，并将其应用于焕肤（去角质）、协同治疗和调节皮肤局部疾病，如皮肤老化、皱纹、痤疮、红斑痤疮、老年斑、口腔溃疡、妊娠纹、丘疹、皮肤发红以及干性皮肤皲裂、脱皮和脱屑等。通过原位法生产的大多数 HA 衍生物不会造成 AHA 和 BHA 常见的皮肤刺激和皮肤发红现象，同时也不会失去对皮肤有益的功效。这些组合物可以是传统的水和油乳剂、脂质体、悬浮液、胶体、溶液、面膜、泥浆、精华液、喷雾剂、凝胶、乳液、膏霜、清洁剂和无水体系，因此可提供多种配方选择，以满足消费者的吸引力和接受度要求。
• Ascorbic acid salts of organic bases with enhanced bioavailability for synergictic anti-aging and skin protective cosmetic compositions
  申请人：——

  公开号：US20040067890A1

  公开（公告）日：2004-04-08

  This invention relates to in-situ preparation, and stable topical delivery systems of ascorbic acid salts of organic bases that provide skin beneficial properties, including reduction in signs of skin aging, anti-wrinkle, anti-oxidant, and photo-protection from UV and sunlight. The formulation avoids the use of oils, minimizes the importance of the pH of the formulation, allows the incorporation of an aqueous solution of ascorbic acid or alkali metal salts of ascorbic acid in the formulation, does not require packaging the formulation in air tight containers, allows the use of large amounts of ascorbic acid, its salts, and its derivatives, and does not require the use of expensive coatings. Moreover, several ascorbic acid derivatives of different chemical composition can be made in a stable topical formulation by the in-situ combination of readily available starting materials in a water solution, despite the understanding well known in the prior art that such compositions in water are inherently unstable. The in-situ method also permits the preparation of novel ascorbic acid derivatives that are not known in the prior art.
• Application of [Hcpy]HSO₄ Brönsted Acidic Ionic Liquid for the Synthesis of Aryl Iodides from Aromatic Amines
  作者：Abdol Reza Hajipour、Mohadeseh Seddighi

  DOI：10.1080/00304948.2011.582384

  日期：2011.1
• Pyridinium-Based Brønsted Acidic Ionic Liquid as a Highly Efficient Catalyst for One-Pot Synthesis of Dihydropyrimidinones
  作者：Abdol R. Hajipour、Mohadeseh Seddighi

  DOI：10.1080/00397911.2010.523488

  日期：2012.1.15

  Abstract In this work, the synthesis and characterization of 3-carboxypyridinium hydrogensulfate ([Hcpy]HSO4) as a new Brønsted acidic ionic liquid are reported. This reusable, inexpensive, and green catalyst was employed for one-pot condensation of 1,3-dicarbonyl compounds, aromatic aldehydes and urea or thiourea for the synthesis of the corresponding 3,4-Dihydropyrimidin-2(1H)-ones. The reactions were

  摘要 在这项工作中，报道了 3-羧基吡啶鎓硫酸氢盐 ([Hcpy]HSO4) 作为一种新的 Brønsted 酸性离子液体的合成和表征。这种可重复使用、廉价且绿色的催化剂用于 1,3-二羰基化合物、芳香醛和尿素或硫脲的一锅缩合反应，以合成相应的 3,4-二氢嘧啶-2(1H)-酮。反应在无溶剂和绿色条件下进行。该程序在很短的反应时间内以极好的收率得到了产物。图形概要