6-O-α-L-rhamnopyranosyl-16,24-di-O-β-D-glucopyranosyl-3β,6α,16β,24(S),25-pentahydroxy-cycloartane | 1158818-37-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6-O-α-L-rhamnopyranosyl-16,24-di-O-β-D-glucopyranosyl-3β,6α,16β,24(S),25-pentahydroxy-cycloartane
• 英文别名: (2R,3R,4R,5R,6S)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-6-hydroxy-15-[(2R,5S)-6-hydroxy-6-methyl-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyheptan-2-yl]-7,7,12,16-tetramethyl-14-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-methyloxane-3,4,5-triol
• CAS: 1158818-37-1
• 化学式: C₄₈H₈₂O₁₉
• 分子量: 963.168
• InChiKey: WCJMPVBZXRBMHR-WWULRHAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  67
• 可旋转键数：
  13
• 环数：
  8.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  318
• 氢给体数：
  13
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  6-O-α-L-rhamnopyranosyl-16,24-di-O-β-D-glucopyranosyl-3β,6α,16β,24(S),25-pentahydroxy-cycloartane 在 盐酸 、 水 作用下， 反应 4.0h， 生成 L-鼠李糖 、 葡萄糖
  参考文献：
  名称：

  Cycloartane-type glycosides from Astragalus amblolepis

  摘要：

  Five cycloartane-type triterpene glycosides were isolated from the methanol extract of the roots of Astragalus amblolepis Fischer along with one known saponin, 3-O-beta-D-xylopyranosyl-16-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane. Structures of the compounds were established as 3-O-beta-D-xylopyranosyl-25-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 3-O-[beta-D-glucuronopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-25-O-beta-D-glucopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxy-cycloartane, 3-O-beta-D-xylopyranosyl-24,25-di-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,24-di-O-beta-D-glucopyranosyl-3 beta, 6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,25-di-O-beta-D-glucopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxy-cycloartane by using 1D and 2D-NMR techniques and mass spectrometry. To the best of our knowledge, the glucuronic acid moiety in cycloartanes is reported for the first time. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2009.03.006

文献信息

• Cycloartane-type glycosides from Astragalus amblolepis
  作者：Emre Polat、Ozgen Caliskan-Alankus、Angela Perrone、Sonia Piacente、Erdal Bedir

  DOI：10.1016/j.phytochem.2009.03.006

  日期：2009.3

  Five cycloartane-type triterpene glycosides were isolated from the methanol extract of the roots of Astragalus amblolepis Fischer along with one known saponin, 3-O-beta-D-xylopyranosyl-16-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane. Structures of the compounds were established as 3-O-beta-D-xylopyranosyl-25-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 3-O-[beta-D-glucuronopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]-25-O-beta-D-glucopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxy-cycloartane, 3-O-beta-D-xylopyranosyl-24,25-di-O-beta-D-glucopyranosyl-3 beta,6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,24-di-O-beta-D-glucopyranosyl-3 beta, 6 alpha,16 beta,24(S),25-pentahydroxy-cycloartane, 6-O-alpha-L-rhamnopyranosyl-16,25-di-O-beta-D-glucopyranosyl-3 beta,6 alpha, 16 beta,24(S),25-pentahydroxy-cycloartane by using 1D and 2D-NMR techniques and mass spectrometry. To the best of our knowledge, the glucuronic acid moiety in cycloartanes is reported for the first time. (C) 2009 Elsevier Ltd. All rights reserved.