8-(Cyclopentyloxy)-7-methoxychroman-4-one oxime | 1001061-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-(Cyclopentyloxy)-7-methoxychroman-4-one oxime
• 英文别名: N-(8-cyclopentyloxy-7-methoxy-2,3-dihydrochromen-4-ylidene)hydroxylamine
• CAS: 1001061-72-8
• 化学式: C₁₅H₁₉NO₄
• 分子量: 277.32
• InChiKey: RJEMIJSZUPNFIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  60.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-(Cyclopentyloxy)-7-methoxychroman-4-one oxime 在 palladium 10% on activated carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 84.0h， 生成 8-(Cyclopentyloxy)-7-methoxychroman-4-amine
  参考文献：
  名称：

  Water-soluble PDE4 inhibitors for the treatment of dry eye

  摘要：

  PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.023
• 作为产物：
  描述：

  8-(Cyclopentyloxy)-7-methoxychroman-4-one 在 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 8-(Cyclopentyloxy)-7-methoxychroman-4-one oxime
  参考文献：
  名称：

  Water-soluble PDE4 inhibitors for the treatment of dry eye

  摘要：

  PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.023

文献信息

• BICYCLIC HETEROARYL INHIBITORS OF PDE4
  申请人：Govek Steven P.

  公开号：US20090291950A1

  公开（公告）日：2009-11-26

  The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

  本发明涉及化合物和方法，可用作磷酸二酯酶4（PDE4）的抑制剂，用于治疗或预防炎症性疾病和其他涉及细胞因子和促炎介质水平升高的疾病。
• Water-soluble PDE4 inhibitors for the treatment of dry eye
  作者：Steven P. Govek、Guy Oshiro、John V. Anzola、Clay Beauregard、Jasmine Chen、Avery R. Coyle、Daniel A. Gamache、Mark R. Hellberg、Jennifer N. Hsien、Julia M. Lerch、John C. Liao、James W. Malecha、Lena M. Staszewski、David J. Thomas、John M. Yanni、Stewart A. Noble、Andrew K. Shiau

  DOI：10.1016/j.bmcl.2010.03.023

  日期：2010.5

  PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats. (C) 2010 Elsevier Ltd. All rights reserved.