1-propyl p-fluorobenzoate | 2928-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-propyl p-fluorobenzoate
• 英文别名: 4-Fluor-benzoesaeure-propylester；n-Propyl-p-fluorbenzoat；4-Fluorobenzoic acid, propyl ester；propyl 4-fluorobenzoate
• CAS: 2928-10-1
• 化学式: C₁₀H₁₁FO₂
• mdl: MFCD04340724
• 分子量: 182.195
• InChiKey: BPFNAFOPXQNMRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙醇 、 对氟苯甲醛 在 双氧水 作用下， 反应 20.0h， 以96%的产率得到1-propyl p-fluorobenzoate
  参考文献：
  名称：

  Oxidative esterification of alcohols and aldehydes using supported iron oxide nanoparticle catalysts

  摘要：

  The synthesis of esters has become an important industrial methodology over the past years because of the role that they serve in the chemical industry. In this study, we present the use of a novel catalyst for the direct conversion of aldehydes into esters. The yields obtained using supported iron oxide nanoparticle catalysts (FeNP) are very high (>90%). The catalyst is also shown to be very stable as shown by the recyclability study (up to 11 times). (C) 2014 Published by Elsevier B.V.

  DOI：

  10.1016/j.catcom.2014.09.022

文献信息

• [EN] LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF<br/>[FR] PROMEDICAMENTS DE LEVODOPA, ET COMPOSITIONS ET UTILISATIONS ASSOCIEES
  申请人：XENOPORT INC

  公开号：WO2005121069A1

  公开（公告）日：2005-12-22

  Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. Wherein Q is selected from X-CO-, and -CO-X-; X is selected from-O-, and -NR6-; n is an integer from 2 to 4; R5 is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl; and when Q is -X--CO-, R5 is further selected from alkoxy, substituted alkoxy, cycloalkoxy, and substituted cycloalkoxy.

  左多巴前药、制备左多巴前药的方法、使用左多巴前药的方法以及左多巴前药的组合物被披露。其中Q从X-CO-和-CO-X-中选择；X从-O-和-NR6-中选择；n是2到4之间的整数；R5从氢、烷基、取代烷基、芳基、取代芳基、芳基烷基、取代芳基烷基、环烷基、取代环烷基、杂原子烷基、取代杂原子烷基、环杂原子烷基、取代环杂原子烷基、杂原子芳基、取代杂原子芳基、杂原子芳基烷基和取代杂原子芳基烷基中选择；当Q为-X--CO-时，R5进一步从烷氧基、取代烷氧基、环烷氧基和取代环烷氧基中选择。
• PYRIDINE DERIVATIVES
  申请人：Asana BioSciences, LLC

  公开号：US20170073339A1

  公开（公告）日：2017-03-16

  The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CYP17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.

  本申请提供了新型吡啶化合物及其药学上可接受的盐或前药。还提供了制备这些化合物的方法。通过向患者投入一种或多种化合物的治疗有效剂量，这些化合物可用于抑制CYP17活性。通过这样做，这些化合物可有效治疗与CYP17活性有关的疾病。这些化合物可用于治疗多种疾病，包括以异常细胞增殖为特征的疾病。在一种实施方式中，该疾病是癌症，如前列腺癌。
• Levodopa prodrugs, and compositions and uses thereof
  申请人：Xiang Jia-Ning

  公开号：US20050282891A1

  公开（公告）日：2005-12-22

  Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.

  本发明揭示了左旋多巴的前药、制备左旋多巴前药的方法、使用左旋多巴前药的方法以及左旋多巴前药的组合物。
• LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
  申请人：Xiang Jia-Ning

  公开号：US20100197953A9

  公开（公告）日：2010-08-05

  Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.

  本文披露了左旋多巴的前药、制备左旋多巴前药的方法、使用左旋多巴前药的方法以及左旋多巴前药的组合物。
• Multicomponent Reaction: Palladium-Catalyzed Carbonylation of Aryl Halides and Alkyl Halides to Aromatic Esters
  作者：Fengxiang Zhu、Pengpeng Yin、Pengbo Zhang

  DOI：10.1021/acs.joc.2c01794

  日期：——

  A convenient four-component reaction has been developed that allows for the direct transformation of aryl iodides with alkyl halides into the corresponding aromatic esters and diesters via palladium-catalyzed carbonylation with water as solvent. Various esters and diesters were isolated in moderate to good yields with broad functional group tolerance.

  已经开发出一种方便的四组分反应，允许通过钯催化的以水为溶剂的羰基化将芳基碘与烷基卤化物直接转化为相应的芳族酯和二酯。各种酯和二酯以中等到良好的收率分离，具有广泛的官能团耐受性。