1-(o-Dimethylaminophenyl)-cyclohexanol | 13288-48-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(o-Dimethylaminophenyl)-cyclohexanol
• 英文别名: 1-[2-(Dimethylamino)phenyl]cyclohexanol；1-[2-(dimethylamino)phenyl]cyclohexan-1-ol
• CAS: 13288-48-7
• 化学式: C₁₄H₂₁NO
• 分子量: 219.327
• InChiKey: DFRVSYRQVKFYDX-UHFFFAOYSA-N

物化性质

• 沸点：
  97 °C(Press: 0.07 Torr)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(o-Dimethylaminophenyl)-cyclohexanol 在 硫酸 作用下， 生成 1-<2-Dimethylamino-phenyl>-cyclohexen
  参考文献：
  名称：

  Metallation of N,N-Dimethylaniline^1a

  摘要：

  DOI：

  10.1021/jo01345a001
• 作为产物：
  描述：

  环己酮 、 N,N-二甲基苯胺 在 正丁基锂 、 四甲基乙二胺 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 4.0h， 以78%的产率得到1-(o-Dimethylaminophenyl)-cyclohexanol
  参考文献：
  名称：

  Bidentate N, O-aluminum complexes: Synthesis, characterization and catalytic study for MPV reduction reactions

  摘要：

  Treatment of AlMe3 with bidentate N, O-ligands, HOC(Me)(Ph)C6H4-NMe2-2 ((LH)-H-1) or HOC(CH2)(5)C6H4 -NMe2-2 ((LH)-H-2) in different molar ratios, four novel aluminum complexes [Me2AlOC(Me)(C6H5)C6H4-NMe2-2] (1), [Me2AlOC(CH2)C6H4-NMe2-2] (2), [Me2Al{OC(Me)(C6H5)C6H4-NMe2-2}(2)] (3) and [Me2Al{OC(CH2)(5)C6H4-NMe2-2}(2)] (4) were obtained in good yield. Complexes 1-4 were characterized by 1H and 13C NMR spectroscopy, elemental analyses and single crystal X-ray diffraction techniques. Each of the complexes 1, 2, 3 and 4 was tested for the capable of catalyzed Meerwein Ponndorf Verley (MPV) reduction of ketones or aldehydes with low catalyst loadings under mild conditions and showed good to excellent catalytic activities. (C) 2015 Elsevier BY. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2015.06.011

文献信息

• Bidentate N, O-aluminum complexes: Synthesis, characterization and catalytic study for MPV reduction reactions
  作者：Yupeng Hua、Zhiqiang Guo、Hongyi Suo、Xuehong Wei

  DOI：10.1016/j.jorganchem.2015.06.011

  日期：2015.10

  Treatment of AlMe3 with bidentate N, O-ligands, HOC(Me)(Ph)C6H4-NMe2-2 ((LH)-H-1) or HOC(CH2)(5)C6H4 -NMe2-2 ((LH)-H-2) in different molar ratios, four novel aluminum complexes [Me2AlOC(Me)(C6H5)C6H4-NMe2-2] (1), [Me2AlOC(CH2)C6H4-NMe2-2] (2), [Me2AlOC(Me)(C6H5)C6H4-NMe2-2}(2)] (3) and [Me2AlOC(CH2)(5)C6H4-NMe2-2}(2)] (4) were obtained in good yield. Complexes 1-4 were characterized by 1H and 13C NMR spectroscopy, elemental analyses and single crystal X-ray diffraction techniques. Each of the complexes 1, 2, 3 and 4 was tested for the capable of catalyzed Meerwein Ponndorf Verley (MPV) reduction of ketones or aldehydes with low catalyst loadings under mild conditions and showed good to excellent catalytic activities. (C) 2015 Elsevier BY. All rights reserved.
• Metallation of N,N-Dimethylaniline^1a
  作者：Arthur R. Lepley、Wajid A. Khan、Armida B. Giumanini、Angelo G. Giumanini

  DOI：10.1021/jo01345a001

  日期：1966.7