N-(phenyl(p-tolyl)methyl)benzenesulfonamide | 35921-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(phenyl(p-tolyl)methyl)benzenesulfonamide
• 英文别名: N-[(4-methylphenyl)-phenylmethyl]benzenesulfonamide
• CAS: 35921-73-4
• 化学式: C₂₀H₁₉NO₂S
• 分子量: 337.442
• InChiKey: ZLPVKKDHZDNWCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯磺酰胺 、 4-甲基二苯甲醇 在 phosphotungstic acid 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以90%的产率得到N-(phenyl(p-tolyl)methyl)benzenesulfonamide
  参考文献：
  名称：

  磷钨酸催化醇的酰胺化

  摘要：

  在 12-磷钨酸存在下，二苯甲基、苄基、烯丙醇和简单脂肪醇与磺酰胺、苯甲酰胺和 4-硝基苯胺的温和亲核取代反应作为一种高效、环保、廉价且耐空气和耐湿的催化剂已经研究了 C-N 键的构建。胺衍生物以良好的产率（高达 98%）获得。12-磷钨酸的可重复使用特性使该协议更具吸引力。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008）

  DOI：

  10.1002/ejoc.200800413

文献信息

• Amberlyst-15 in Ionic Liquid: An Efficient and Recyclable Reagent for Nucleophilic Substitution of Alcohols and Hydroamination of Alkenes
  作者：Ziyauddin S. Qureshi、Krishna M. Deshmukh、Pawan J. Tambade、Kishor P. Dhake、Bhalchandra M. Bhanage

  DOI：10.1002/ejoc.201000456

  日期：2010.11

  The nucleophilic substitution reaction of secondary alcohols and hydroamination of alkenes with amides, sulfonamides, carbamates, and amines using Amberlyst-15 immobilized in [Bmim][BF 4] (1-butyl-3-methylimidazolium tetrafluoroborate) ionic liquid as an efficient recyclable reagent is described. The solvent effect is prominent in the reaction, and the desired substitution products are obtained in

  使用固定在 [Bmim][BF 4]（1-丁基-3-甲基咪唑鎓四氟硼酸盐）离子液体中的 Amberlyst-15 作为有效的可回收试剂，仲醇的亲核取代反应和烯烃与酰胺、磺酰胺、氨基甲酸酯和胺的加氢胺化反应被描述。反应中溶剂效应显着，以良好至极好的收率获得了所需的取代产物。由于易于处理试剂、简单的后处理程序以及允许有效回收的环境友好条件，该协议是有利的。
• The mechanism of hydroxylation of organometallic reagents by 2-sulfonyloxaziridines
  作者：Franklin A. Davis、Jia Wei、Aurelia C. Sheppard、Steven Gubernick

  DOI：10.1016/s0040-4039(00)95605-3

  日期：——

  The hydroxylation of organometallic reagents (RM) by 2-sulfonyloxaziridines 1 is shown to involve a hemiaminal intermediate 2, whose stability is apparently related to the nucleophilicity of the hydroxylated product (ROH).

  已显示2-磺酰基恶唑烷1对有机金属试剂（RM）的羟基化作用涉及半胱氨酸中间体2，该中间体的稳定性显然与羟基化产物（ROH）的亲核性有关。
• Phosphinite- and phosphite-based type I palladacycles as highly active catalysts for addition reactions of arylboronic acids with aldehydes, α,β-unsaturated ketones, α-ketoesters, and aldimines
  作者：Ping He、Yong Lu、Qiao-Sheng Hu

  DOI：10.1016/j.tetlet.2007.05.119

  日期：2007.7

  Phosphinite- and phosphite-based type I palladacycle-catalyzed additions of arylboronic acids with aldehydes, alpha,beta-unsaturated ketones, alpha-ketoesters, and aldimines are described. Our study showed that readily available phosphinite- and phosphite-based type I palladacycles could possess higher catalytic activity than phosphine-based palladacycles and were highly active, practical catalysts. Our study may pave the road for development of optically active phosphinite- and phosphite-based palladacycles for asymmetric catalysis. (C) 2007 Elsevier Ltd. All rights reserved.
• DAVIS, FRANKLIN A.;WEI, JIA;SHEPPARD, AURELIA C.;GUBERNICK, STEVEN, TETRAHEDRON LETT., 28,(1987) N 43, 5115-5118
  作者：DAVIS, FRANKLIN A.、WEI, JIA、SHEPPARD, AURELIA C.、GUBERNICK, STEVEN

  DOI：——

  日期：——