D-Phe-ol hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: D-Phe-ol hydrochloride
• 英文别名: L-phenylglycinol hydrochloride；(R)-2-amino-3-phenylpropanol hydrochloride；(R)-2-Amino-3-phenylpropan-1-ol hydrochloride；(2R)-2-amino-3-phenylpropan-1-ol;hydrochloride
• 化学式: C₉H₁₃NO*ClH
• 分子量: 187.669
• InChiKey: XRTJOZQBTFJAMF-SBSPUUFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  D-Phe-ol hydrochloride 生成 D-苯丙氨醇
  参考文献：
  名称：

  BOERNER, A.;KRAUSE, H. -W., PHARMAZIE, 45,(1990) N, C. 531-532

  摘要：

  DOI：
• 作为产物：
  描述：

  (1S,2S)-(+)-2-氨基-1-[4-(甲硫基)苯基-1,3-丙二醇 在 盐酸 、 Raney-Ni W-2 、 potassium carbonate 作用下， 以 乙醇 、 乙二醇 、 甘油 为溶剂， 反应 35.0h， 生成 D-Phe-ol hydrochloride
  参考文献：
  名称：

  由（1 S，2 S）-（+）-硫代氨基氰胺合成简明的（R）-（+）-苯丙氨醇

  摘要：

  （R）-（+）-苯丙氨醇6是通过阮内镍的作用从衍生自（1S，2S）-2-氨基-1-芳基-1,3-丙二醇1和2的恶唑啉3和4获得的。通过水解中间体苯甲酰胺5。

  DOI：

  10.1016/s0957-4166(98)00129-3

文献信息

• Process for lowering the viscosity of highly concentrated protein solutions
  申请人：ADOCIA

  公开号：US20140044708A1

  公开（公告）日：2014-02-13

  A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8. The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.

  将溶液的粘度降低的过程包括准备一种溶液，其中包括化合物I的化合物，在最终配方中的浓度在10至250mM之间，并且含有至少一种抗体片段的蛋白质，其浓度在50至350mg/mL之间，pH在5至8之间。 该化合物将溶液的粘度降低至少15％，相对于不含该化合物的具有相同浓度和相同pH值的至少一种含有至少一种抗体片段的蛋白质溶液的粘度。
• Aerobic Amide Bond Formation with <i>N</i> ‐hydroxysuccinimide
  作者：Haoyi Yao、Kana Yamamoto

  DOI：10.1002/asia.201200017

  日期：2012.7

  Breathe easy: Molecular oxygen is one of the most abundant, atom‐efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc)2 and N‐hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

  轻松呼吸：分子氧是最丰富，原子效率最高且最经济的氧化剂之一。据报道，由醛和胺形成的好氧氧化酰胺。该方法使用催化量的Co（OAc）2和N-羟基琥珀酰亚胺作为反应促进剂。它适用于手性底物，而不会损失其光学纯度。
• Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases
  作者：Natalie A. Dales、Regine S. Bohacek、Kenneth A. Satyshur、Daniel H. Rich

  DOI：10.1021/ol0160912

  日期：2001.7.1

  synthesis, and enzyme inhibition of a new class of aspartic peptidase inhibitors is described. Unsymmetrical ureas were designed from computer-generated structures. Using mechanism-based and substrate-based design techniques, potent pepsin inhibitors were developed and the binding mode was established. Two X-ray crystal structures of enzyme-bound inhibitors revealed a new binding mode that is closely related

  [结构：见正文]描述了新型天冬氨酸肽酶抑制剂的设计，合成和酶抑制作用。从计算机生成的结构设计不对称脲。使用基于机制和基于底物的设计技术，开发了有效的胃蛋白酶抑制剂并建立了结合模式。酶结合抑制剂的两个X射线晶体结构揭示了一种新的结合模式，该模式与计算机生成的结合模式密切相关。
• Oxoammonium Salt-Promoted Multifunctionalization of Saturated Cyclic Amines Based On β-Oxo Cyclic Iminium Ion Intermediates
  作者：Yan He、Qimeng Liu、Jintao Yang、Zhi Zheng、Guo-Li Chai、Xinying Zhang、Xuesen Fan

  DOI：10.1021/acs.orglett.2c03253

  日期：2022.10.28

  C(sp3)–H bond functionalization of saturated cyclic amines through oxoammonium salt-promoted oxidation to afford a β-oxo cyclic iminium ion as a key intermediate, followed by cascade addition with thiocyanate and diverse N-, O-, and S-containing nucleophiles in the green solvent and EtOH. Notably, chiral spiro azapolyheterocycles were prepared enantioselectively (>20:1 dr, up to 99% ee) when cysteine or

  在此，我们描述了一种通过氧铵盐促进氧化对饱和环胺进行多 C(sp 3 )–H 键功能化的简便方法，以提供 β-氧环亚胺离子作为关键中间体，然后与硫氰酸盐和多种 N 进行级联加成绿色溶剂和 EtOH 中含有 -、O- 和 S 的亲核试剂。值得注意的是，当使用半胱氨酸或丝氨酸酯作为底物时，可以对映选择性地制备手性螺氮杂多杂环化合物（>20:1 dr，高达 99% ee）。此外，利用该方法还完成了多种天然产物衍生物的简洁后期修饰。
• The anandamide membrane transporter. Structure–activity relationships of anandamide and oleoylethanolamine analogs with phenyl rings in the polar head group region
  作者：Vincenzo Di Marzo、Alessia Ligresti、Enrico Morera、Marianna Nalli、Giorgio Ortar

  DOI：10.1016/j.bmc.2004.07.026

  日期：2004.10

  A new series of anandamide and N-oleoylethanolamine analogs, most of which with aromatic moieties in the head group region, has been synthesized and evaluated as inhibitors of anandamide uptake. Some of them efficaciously inhibit the uptake process with K-i values in the low micromolar range (2.4-21.2 muM). Strict structural requisites are needed to observe a significant inhibition and in no case inhibition of fatty acid amidohydrolase overlaps with inhibition of anandamide uptake. (C) 2004 Elsevier Ltd. All rights reserved.