diisopropyl(o-isopropylphenyl)phosphane | 1085850-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diisopropyl(o-isopropylphenyl)phosphane
• 英文别名: Di(propan-2-yl)-(2-propan-2-ylphenyl)phosphane
• CAS: 1085850-81-2
• 化学式: C₁₅H₂₅P
• 分子量: 236.337
• InChiKey: JJPBEYGLMZBIFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dichloro(cycloocta-1,5-diene)palladium (II) 、 diisopropyl(o-isopropylphenyl)phosphane 以 乙醚 为溶剂， 以82.5%的产率得到trans-dichlorobis[diisopropyl(o-isopropylphenyl)phosphane]palladium(II)
  参考文献：
  名称：

  Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Various Aryl Halides Using ortho ‐Alkyl‐Substituted Arylphosphanes and ( ortho ‐Alkylphenyl)alkylphosphanes under Microwave Heating

  摘要：

  AbstractMono‐ and dinuclear palladium(II) chloride complexes of various ortho‐alkyl‐substituted aryl‐ and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P{1H} NMR spectroscopy, X‐ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave‐assisted Suzuki–Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron‐rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200700705
• 作为产物：
  描述：

  1-溴-2-异丙基苯 、 氯二异丙基膦 在 正丁基锂 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以94.6%的产率得到diisopropyl(o-isopropylphenyl)phosphane
  参考文献：
  名称：

  Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Various Aryl Halides Using ortho ‐Alkyl‐Substituted Arylphosphanes and ( ortho ‐Alkylphenyl)alkylphosphanes under Microwave Heating

  摘要：

  AbstractMono‐ and dinuclear palladium(II) chloride complexes of various ortho‐alkyl‐substituted aryl‐ and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P{1H} NMR spectroscopy, X‐ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave‐assisted Suzuki–Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron‐rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200700705

文献信息

• Palladium‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Various Aryl Halides Using <i>ortho</i> ‐Alkyl‐Substituted Arylphosphanes and ( <i>ortho</i> ‐Alkylphenyl)alkylphosphanes under Microwave Heating
  作者：Sauli Vuoti、Juho Autio、Minna Laitila、Matti Haukka、Jouni Pursiainen

  DOI：10.1002/ejic.200700705

  日期：2008.1

  AbstractMono‐ and dinuclear palladium(II) chloride complexes of various ortho‐alkyl‐substituted aryl‐ and alkylphosphanes were prepared. Subsequently, these were characterized by 1H NMR and 31P1H} NMR spectroscopy, X‐ray crystallographic studies and mass spectroscopy. The palladium complexes were screened as potential catalysts for the microwave‐assisted Suzuki–Miyaura coupling reaction of several aryl halides under aerobic conditions. A preliminary study showed that excellent results can be obtained even for electron‐rich bromides and unactivated aryl chlorides with an optimized solvent, base and catalyst loading using specific phosphane ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)