2-[2-(2-Methylpropyl)imidazo[4,5-b]pyridin-3-yl]ethanamine | 1441931-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-[2-(2-Methylpropyl)imidazo[4,5-b]pyridin-3-yl]ethanamine
• 英文别名: 2-[2-(2-methylpropyl)imidazo[4,5-b]pyridin-3-yl]ethanamine
• CAS: 1441931-90-3
• 化学式: C₁₂H₁₈N₄
• 分子量: 218.302
• InChiKey: XMNOLJOTLIMDBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 水 、 铁粉 、 氯化铵 作用下， 以 乙醇 为溶剂， 以28%的产率得到2-[2-(2-Methylpropyl)imidazo[4,5-b]pyridin-3-yl]ethanamine
  参考文献：
  名称：

  A simple two-step access to diversely substituted imidazo[4,5-b]pyridines and benzimidazoles from readily available 2-imidazolines

  摘要：

  We discovered a facile rearrangement of N-(hetero)aryl 2-imidazolines into diversely substituted imidazo[4,5-b]pyridines and benzimidazoles, under Bechamp reduction conditions. Combined with the earlier reported protocol for Pd-catalyzed (hetero)arylation of 2-imidazolines, it provides a simple two-step access to a range of compounds based on these medicinally important heterocyclic cores. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.036

文献信息

• A simple two-step access to diversely substituted imidazo[4,5-b]pyridines and benzimidazoles from readily available 2-imidazolines
  作者：Prashant Mujumdar、Tanja Grkovic、Mikhail Krasavin

  DOI：10.1016/j.tetlet.2013.04.036

  日期：2013.6

  We discovered a facile rearrangement of N-(hetero)aryl 2-imidazolines into diversely substituted imidazo[4,5-b]pyridines and benzimidazoles, under Bechamp reduction conditions. Combined with the earlier reported protocol for Pd-catalyzed (hetero)arylation of 2-imidazolines, it provides a simple two-step access to a range of compounds based on these medicinally important heterocyclic cores. (C) 2013 Elsevier Ltd. All rights reserved.