2-methyl-1,1-bis-methylsulfanyl-propane | 63882-89-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 2-methyl-1,1-bis-methylsulfanyl-propane
• 英文别名: isobutyraldehyde dimethyl dithioacetal；1,1-Bis(methylthio)-2-methylpropane；2-methyl-1,1-bis(methylsulfanyl)propane
• CAS: 63882-89-3
• 化学式: C₆H₁₄S₂
• 分子量: 150.309
• InChiKey: VQUIXMGMUWVWNV-UHFFFAOYSA-N

物化性质

• 沸点：
  190.7±13.0 °C(Predicted)
• 密度：
  0.961±0.06 g/cm3(Predicted)
• 保留指数：
  1415

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲基甲硫基硅烷 、 异丁醛 在 zinc(II) iodide 作用下， 以 乙醚 为溶剂， 生成 2-methyl-1,1-bis-methylsulfanyl-propane
  参考文献：
  名称：

  Thiosilanes, a promising class of reagents for selective carbonyl protection

  摘要：

  DOI：

  10.1021/ja00457a020

文献信息

• DEOXYGENATIVE THIOACETALIZATION OF CARBONYL COMPOUNDS WITH ORGANIC DISULFIDE AND TRIBUTYLPHOSPHINE
  作者：Masato Tazaki、Makoto Takagi

  DOI：10.1246/cl.1979.767

  日期：1979.7.5

  A new deoxygenative thioether formation from carbonyl compounds as well as epoxides is presented (eq. 1–3). The reaction proceeds with the combined use of alkyl or aryl disulfide and tributylphosphine under neutral and mild conditions. The reaction with aldehydes proceeds with special ease to give thioacetals in high yields, and can be a valuable synthetic reaction.

  提出了一种由羰基化合物和环氧化物形成的新脱氧硫醚（方程式 1-3）。在中性和温和条件下，该反应在烷基或芳基二硫化物和三丁基膦的组合使用下进行。与醛的反应特别容易以高产率得到硫代缩醛，并且可以是有价值的合成反应。
• INSECTICIDE FOR AGRICULTURAL OR HORTICULTURAL USE AND METHOD OF USE THEREOF
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1661886A1

  公开（公告）日：2006-05-31

  An object of the present invention is to provide insecticides having high effectiveness. The present invention provides compounds represented by formula (1): wherein A1, A2, A3, and A4 independently represent a carbon atom, a nitrogen atom, or an oxidized nitrogen atom; R1 represents a C1-C6 alkyl group which may be substituted, a phenyl group which may be substituted, or a heterocyclic group which may be substituted; R2 and R3 independently represent a hydrogen atom, a C1-C4 alkyl group which may be substituted, or a C1-C4 alkylcarbonyl group which may be substituted; G1, G2, and G3 independently represent an oxygen atom or a sulfur atom; Xs may be the same or different and each represent a hydrogen atom, a halogen atom, a C1-C4 alkyl group which may be substituted, or an amino group which may be substituted; n represents an integer of 0 to 4; Q represents a phenyl group which may be substituted, a naphthyl group which may be substituted, a tetrahydronaphthyl group which may be substituted, or a heterocyclic group which may be substituted, insecticides containing the compounds as active ingredients, and a method for producing the compounds. The compounds represented by formula (1) exhibit an excellent preventive effect as insecticides and also exhibit an excellent preventive effect when being combined with another insecticide, an acaricide, a nematocide, a fungicide, a herbicide, a plant growth regulator, or a biological pesticide.

  本发明的目的是提供高效杀虫剂。本发明提供由式（1）代表的化合物： 其中 A1、A2、A3 和 A4 独立地代表碳原子、氮原子或氧化氮原子；R1 代表可被取代的 C1-C6 烷基、可被取代的苯基或可被取代的杂环基；R2 和 R3 独立地代表氢原子、可被取代的 C1-C4 烷基或可被取代的 C1-C4 烷基羰基；G1、G2 和 G3 独立地代表氧原子或硫原子；Xs可以相同或不同，各自代表氢原子、卤素原子、可被取代的C1-C4烷基或可被取代的氨基；n代表0至4的整数；Q代表可被取代的苯基、可被取代的萘基、可被取代的四氢萘基或可被取代的杂环基，含有这些化合物作为活性成分的杀虫剂，以及生产这些化合物的方法。 式（1）所代表的化合物作为杀虫剂具有极佳的预防效果，当与另一种杀虫剂、杀螨剂、杀线虫剂、杀真菌剂、除草剂、植物生长调节剂或生物农药结合使用时，也具有极佳的预防效果。
• TAZAKI MASATO; TAKAGI MAKOTO, CHEM. LETT., 1979, NO 7, 767-770
  作者：TAZAKI MASATO、 TAKAGI MAKOTO

  DOI：——

  日期：——
• QUINAZOLINYL-INDAZOLE DERIVATIVES AND THEIR USE AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：ViiV HEALTHCARE UK (NO.5) LIMITED

  公开号：US20210403465A1

  公开（公告）日：2021-12-30

  Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth:
• [EN] TREATMENT OF EPILEPTIC CONDITIONS WITH GABAA RECEPTOR MODULATORS<br/>[FR] TRAITEMENT D'AFFECTIONS ÉPILEPTIQUES AVEC DES MODULATEURS DU RÉCEPTEUR GABAA
  申请人：NEUROCYCLE THERAPEUTICS INC

  公开号：WO2021081357A1

  公开（公告）日：2021-04-29

  Disclosed herein are GABAA receptor modulators and compositions comprising GABAA receptor modulators for treatment of epileptic conditions. Also disclosed herein are methods of treating epileptic conditions in a subject by administering a GABAA receptor modulators or composition as described herein.