5-ethyl-2-(2-pyrrolidino-ethyl)-pyridine | 91904-22-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-ethyl-2-(2-pyrrolidino-ethyl)-pyridine
• 英文别名: 5-Aethyl-2-(2-pyrrolidino-aethyl)-pyridin；5-Ethyl-2-<2-pyrrolidino-ethyl>-pyridin；5-Ethyl-2-(2-pyrrolidin-1-ylethyl)pyridine
• CAS: 91904-22-2
• 化学式: C₁₃H₂₀N₂
• 分子量: 204.315
• InChiKey: LTRFAPGENZNRNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-乙基-2-甲基-吡啶 在 氢氧化钾 、 甲酸 、 水 、 溶剂黄146 作用下， 175.0~240.0 ℃ 、18.53 MPa 条件下， 生成 5-ethyl-2-(2-pyrrolidino-ethyl)-pyridine
  参考文献：
  名称：

  Profft, Chemiker-Zeitung, Chemische Apparatur, 1957, vol. 81, p. 427,429

  摘要：

  DOI：

文献信息

• Imine Compound
  申请人：Saito Shiuji

  公开号：US20080312435A1

  公开（公告）日：2008-12-18

  An imine compound represented by the formula: wherein A represents a heterocyclic group; R 1 , R 2 , an R 3 each represent a hydrogen atom, a halogen atom, a C 1-10 alkyl group optionally substituted with an aryl group(s) substituted with a halogen atom(s), a C 3-10 cycloalkyl group, a C 1-6 haloalkyl group, a C 1-10 alkoxy group, etc.; R 4 represents an optionally substituted C 1-10 alkyl, C 2-6 alkenyl, or aryl group; R 5 represents a hydrogen atom, a C 1-10 alkoxy group, a C 1-6 haloalkyl group, an optionally substituted C 1-10 alkyl or C 2-6 alkenyl group, an optionally substituted aryl or heterocyclic group, etc.; W represents —CO—, —CO—CO—, —CO—NH—, —CS—NH—, or —SO 2 —, or a cannabinoid-receptor agonist comprising said imine compound as an active ingredient. The imine compound of the present invention has a cannabinoid-receptor agonist effect, and is useful as a therapeutic or prophylactic drug for pains and autoimmune diseases.

  一种以以下式表示的亚胺化合物：其中A代表杂环基团；R1、R2和R3分别表示氢原子、卤素原子、C1-10烷基，该烷基可选地取代有芳基，所述芳基取代有卤素原子，C3-10环烷基，C1-6卤代烷基，C1-10烷氧基等；R4表示可选地取代的C1-10烷基，C2-6烯基或芳基；R5表示氢原子，C1-10烷氧基，C1-6卤代烷基，可选地取代的C1-10烷基或C2-6烯基，可选地取代的芳基或杂环基团等；W表示—CO—，—CO—CO—，—CO—NH—，—CS—NH—或—SO2—，或以该亚胺化合物为活性成分的大麻素受体激动剂。本发明的亚胺化合物具有大麻素受体激动剂作用，可用作治疗或预防疼痛和自身免疫性疾病的药物。
• In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series
  作者：Diana L. Nersesian、Lawrence A. Black、Thomas R. Miller、Timothy A. Vortherms、Timothy A. Esbenshade、Arthur A. Hancock、Marlon D. Cowart

  DOI：10.1016/j.bmcl.2007.10.067

  日期：2008.1

  Structure-activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H-3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine. (C) 2007 Elsevier Ltd. All rights reserved.
• Profft, Chemiker-Zeitung, Chemische Apparatur, 1957, vol. 81, p. 427,429
  作者：Profft

  DOI：——

  日期：——