1-[2-(4-Methylphenyl)ethyl]-1H-pyrrole-2,5-dione | 140481-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(4-Methylphenyl)ethyl]-1H-pyrrole-2,5-dione
• 英文别名: 1-[2-(4-methylphenyl)ethyl]pyrrole-2,5-dione
• CAS: 140481-03-4
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.25
• InChiKey: SRFYBKMVPQEVKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
• CD8A-Binding Fibronectin Type III Domains
  申请人：Janssen Biotech, Inc.

  公开号：US20180162927A1

  公开（公告）日：2018-06-14

  Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.