Tetrakis(benzyloxy)titanium | 19803-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tetrakis(benzyloxy)titanium
• 英文别名: titanium tetrabenzyl oxide；benzyl alcohol; titanium tetrabenzylate；Benzylalkohol; Titan-tetrabenzylat；Orthotitansaeure-tetrabenzylester, Tetrabenzylorthotitanat；Titanium tetrakis(benzyl alcoholate)
• CAS: 19803-37-3
• 化学式: 4C₇H₇O*Ti
• 分子量: 476.408
• InChiKey: VXUZHDILTVHAFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.54
• 重原子数：
  9.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  23.06
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  Tetrakis(benzyloxy)titanium 250.0 ℃ 、266.64 Pa 条件下， 生成 二苄醚
  参考文献：
  名称：

  Nesmejanow et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 518,521

  摘要：

  DOI：

文献信息

• Asymmetric halogenation of chiral imide enolates. A general approach to the synthesis of enantiomerically pure α-amino acids.
  作者：David A Evans、Jon A Ellman、Roberta L Dorow

  DOI：10.1016/s0040-4039(00)95305-x

  日期：1987.1

  The chiral N-acyl oxazolidones 2, as the derived dibutyl boron enolates, have been demonstrated to undergo diastereoselective bromination and subsequent azide displacement to give the α-azido carboximides 4a (5 cases). These adducts may be hydrolyzed under mild conditions to the enantiomerically pure α-azido carboxylic acids 5a.

  已证明手性N-酰基恶唑烷酮2（作为衍生的二丁基硼烯醇化物）经历非对映选择性溴化和随后的叠氮化物置换，得到α-叠氮羧酰亚胺4a（5例）。这些加合物可以在温和条件下水解成对映体纯的α-叠氮基羧酸5a。
• The titanium - mediated transesterification of phosphorous esters
  作者：M. Froneman、T.A. Modro

  DOI：10.1016/0040-4039(88)85153-0

  日期：1988.1

  Reaction of alcohols with phosphorous diesters in the presence of titanium tetraalkoxides results in a displacement of both or one ester functions by the RO groups of an alcohol used.

  在四烷氧基钛存在下，醇与磷二酯的反应导致所用醇的RO基团取代了两个或一个酯官能团。
• New Synthesis of Phosphorous and Phosphoric Acid Esters
  作者：M. Froneman、T. A. Modro

  DOI：10.1055/s-1991-26418

  日期：——

  Reaction of alcohols with dialkyl phosphites in the presence of titanium tetraalkoxides results in a displacement of both or one ester function(s) by the RO groups of the alcohol used. The mixed phosphites, (R3O)(R1O)P(O)H, prepared by this method can be used as substrates for the mixed phosphates, (R4O)(R3O)(R1O)PO.

  在四烷氧基钛的存在下，醇与二烷基亚磷酸酯反应，会导致所用醇的 RO 基团取代两个或一个酯官能团。用这种方法制备的混合亚磷酸酯 (R3O)(R1O)P(O)H 可用作混合磷酸盐 (R4O)(R3O)(R1O)PO 的底物。
• A chiral synthesis of (−)-cannabisativine: an application of the highly diastereo-selective hetero Diels-Alder reaction
  作者：Tatsuo Hamada、Tatsuya Zenkoh、Hiroki Sato、Osamu Yonemitsu

  DOI：10.1016/s0040-4039(00)74295-x

  日期：1991.3

  The polyamine alkaloid cannabisativine was synthesized as an optical active form. The key step is the hetero Diels-Alder reaction of chiral diene and an N-tosylimine, in which regio- and diastereo-face selectivities were completely controlled, only one diastereomer was isolated in high yield. Synthesized (−)-cannabisativine has the same physical data as the natural product except for the αD value.

  合成多胺生物碱大麻脂为光学活性形式。关键步骤是手性二烯与N-甲苯磺胺的杂Diels-Alder反应，其中区域和非对映异构体的选择性得到完全控制，仅高产率地分离出一个非对映异构体。除了αD值外，合成的（-）-大麻二酚具有与天然产物相同的物理数据。
• Evans, David A.; Britton, Thomas C.; Ellman, Jonathan A., Journal of the American Chemical Society, 1990, vol. 112, # 10, p. 4011 - 4030
  作者：Evans, David A.、Britton, Thomas C.、Ellman, Jonathan A.、Dorow, Roberta L.

  DOI：——

  日期：——