N-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)hydroxylamine | 26235-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: N-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)hydroxylamine
• 英文别名: N-(4,5,6,7-tetrahydro-1-benzothiophen-4-yl)hydroxylamine
• CAS: 26235-50-7
• 化学式: C₈H₁₁NOS
• 分子量: 169.247
• InChiKey: WWGFQCYZJSUAEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6,7-dihydro-5H-benzo[b]thiophene-4-one oxime 在 盐酸 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 生成 N-(4,5,6,7-tetrahydrobenzo[b]thiophen-4-yl)hydroxylamine
  参考文献：
  名称：

  Regiospecific Rearrangement of Hydroxylamines to Secondary Amines Using Diisobutylaluminum Hydride

  摘要：

  A systematic investigation of a reductive ring-expansion reaction of N-monosubstituted hydroxylamines with diisobutylaluminum hydride (DIBALH) was carried out. The reaction regiospecifically provided a variety of bicyclic or tricyclic heterocycles or linear secondary amines containing nitrogen attached to an aromatic ring.

  DOI：

  10.3987/com-10-s(e)126

文献信息

• Regiospecific Rearrangement of Hydroxylamines to Secondary Amines Using Diisobutylaluminum Hydride
  作者：Hidetsura Cho、Hidetoshi Tokuyama、Kenji Sugimoto、Yusuke Iwama、Nakako Mitsuhashi、Kentaro Okano

  DOI：10.3987/com-10-s(e)126

  日期：——

  A systematic investigation of a reductive ring-expansion reaction of N-monosubstituted hydroxylamines with diisobutylaluminum hydride (DIBALH) was carried out. The reaction regiospecifically provided a variety of bicyclic or tricyclic heterocycles or linear secondary amines containing nitrogen attached to an aromatic ring.