3-Pyrrolidinol, 2-[(1R)-1-methylpropyl]-, (2R)-rel- | 1367629-90-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-Pyrrolidinol, 2-[(1R)-1-methylpropyl]-, (2R)-rel-
• 英文别名: (2S)-2-[(2S)-butan-2-yl]pyrrolidin-3-ol
• CAS: 1367629-90-0
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: HVEKFPZZCASWNV-PPSBICQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Fusion proteins comprising an aldolase enzyme joined to a maltose binding protein
  申请人：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

  公开号：US10683493B2

  公开（公告）日：2020-06-16

  The present invention refers to an enzyme consisting of a fusion protein particularly useful as shown through-out the present invention for carrying out the carbon-carbon bond-forming reaction known as the aldol Reaction, preferably for carrying out an aldol reaction by using aldehydes as substrates and preferably pyruvate or a salt thereof, for producing hydroxyketoacids. Said enzyme is made by binding an aldolase to a maltose binding protein. The enzymes display full activity under “highly denaturing” substrate loadings (aldehydes, >1 M).

  本发明指的是一种由融合蛋白组成的酶，如本发明全文所示，这种酶特别适用于进行称为醛醇反应的碳-碳键形成反应，最好是通过使用醛作为底物，最好是丙酮酸或其盐来进行醛醇反应，以生产羟基酮酸。所述酶是通过将醛缩酶与麦芽糖结合蛋白结合制成的。这种酶在 "高度变性 "底物负荷（醛，>1 M）下显示出全部活性。
• FUSION PROTEINS COMPRISING AN ALDOLASE ENZYME JOINED TO A MALTOSE BINDING PROTEIN
  申请人：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

  公开号：US20190194638A1

  公开（公告）日：2019-06-27

  The present invention refers to an enzyme consisting of a fusion protein particularly useful as shown through-out the present invention for carrying out the carbon-carbon bond-forming reaction known as the aldol Reaction, preferably for carrying out an aldol reaction by using aldehydes as substrates and preferably pyruvate or a salt thereof, for producing hydroxyketoacids. Said enzyme is made by binding an aldolase to a maltose binding protein. The enzymes display full activity under “highly denaturing” substrate loadings (aldehydes, >1 M).